摘要
Among the four equally important major building blocks of life-that is,nucleic acids(DNA and RNA),proteins,lipids,and car-bohydrates(glycans)-the first two,DNA and RNA,follow the well-established principle of the“central dogma”of transcription(DNA to RNA)and translation(RNA to protein).However,the latter two,glycans and lipids,are missing from biology’s central dogma.In fact,there may be an undiscovered law regarding communication between DNA,RNA,glycans,and lipids,and their roles in immunomodulation.Thus,it becomes necessary to ask:Does a paracentral dogma exist?Can glycans be the third life code-after the first and second life codes of nuclei acids and amino acids-for the materiality of the cell?
作者
王嵬
杨宝峰
Wei Wang;Baofeng Yang(The First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;School of Public Health,Shandong First Medical University&Shandong Academy of Medical Sciences,Tai’an 271016,China;Beijing Municipal KeyLaboratory of Clinical Epidemiology,Schoolof Public Health,Capital Medical University,Beijing 100069,China;Centre for Precision Health,Edith Cowan University,Perth,WA6027,Australia;Department of Pharmacology&State-Province Key Laboratories of Biomedicine-Pharmaceutics of China&Key Laboratory of Cardiovascular MedicineResearch,Ministry of Education of the People’s Republic of China,College of Pharmacy,Harbin MedicalUniversity,Harbin 150081,China;Research Unitof Noninfectious ChronicDiseasesin Frigid Zones,ChineseAcademy of Medical Sciences,Harbin 150081,China;Northern Translational Medicine Research and Cooperation Center,Heilongjiang Academy of Medical Sciences,Harbin Medical University,Harbin 150081,China)
