摘要
The central dogma of biology holds that the transcription of DNA into RNA and the translation of RNA into proteins forms the primary axis of biological activity[1].Following major advances in the description of the complex glycan and lipid chains that are added onto these basic building blocks,the glycome and lipidome have recently been added to this doctrine as an exciting new extension named the"paracentral dogma"[2].However,it has been pointed out that biological systems can indude many layers,which are descibed in modern omics technology platforms relat-ing to both cell-intrinsic and cell-extrinsic layers of control,including metabolomic,microbiomic,immunological,epigenomic,epitranscriptomic,proteomic and phosphoproteomic layers[3].
