CXCL10、LPA蛋白在卵巢癌组织中的表达及与预后的关系

Expressions of CXCL10 and LPA Proteins in Ovarian Cancer Tissues and Their Relationship with Prognosis

目的 分析CXC趋化因子配体10(CXCL10)、溶血磷脂酸(LPA)蛋白在卵巢癌组织中的表达及与预后的关系。方法 选取2017年1月—2019年12月行卵巢切除术的103例原发性卵巢癌以及同期60例卵巢良性肿瘤为研究对象。所有患者术后取卵巢组织标本,采用免疫组化法检测CXCL10、LPA蛋白表达情况。比较不同卵巢组织CXCL10、LPA蛋白表达情况,分析CXCL10、LPA蛋白表达与卵巢癌患者临床特征及预后的关系。结果 卵巢癌组织CXCL10、LPA蛋白阳性表达率分别为68.93%(71/103)、75.73%(78/103),高于卵巢良性肿瘤组织的26.67%(16/60)、33.33%(20/60)(P<0.05);CXCL10、LPA蛋白表达与卵巢癌分化程度、国际妇产科联合会分期、腹水、淋巴结转移、肿瘤直径有关(P<0.05,P<0.01),而与年龄、组织学类型无关(P>0.05)。Kaplan-Meier生存曲线分析结果显示,CXCL10、LPA蛋白阳性表达组3年无进展生存率分别为23.94%、20.51%,低于阴性表达组的40.63%、56.00%(P<0.05)。结论 卵巢癌组织中CXCL10与LPA蛋白呈高表达状态,不同临床特征卵巢癌患者CXCL10与LPA蛋白表达存在差异,二者与预后有关。

Objective To analyze the expressions of CXC chemokine ligand 10(CXCL10)and lysophosphatidic acid(LPA)proteins in ovarian cancer tissues and their relationship with prognosis.Methods A total of 103 patients with primary ovarian cancer undergoing ovariectomy between January 2017 and December 2019 and 60 patients with benign ovarian tumors during the same period were enrolled as the research subjects.The ovarian tissue samples of all patients were collected after surgery to detect the expressions of CXCL10 and LPA proteins by immunohistochemistry.The expressions of CXCL10 and LPA proteins in different ovarian tissues were compared,and their relationship with clinical characteristics and prognosis of patients with ovarian cancer was analyzed.Results The positive expression rates of CXCL10 and LPA proteins in ovarian cancer tissues were 68.93%(71/103)and 75.73%(78/103)respectively,which were higher than those in benign ovarian tumor tissues[26.67%(16/60),33.33%(20/60),P<0.05].The expressions of CXCL10 and LPA proteins were related to differentiation degree of ovarian cancer,staging of International Federation of Gynecology and Obstetrics(FIGO),ascites,lymph node metastasis and tumor diameter(P<0.05,P<0.01),but not related to age or histological types(P>0.05).The results of Kaplan-Meier survival curves analysis showed that 3-year progression-free survival rates in CXCL10-positive group and LPA-positive group were 23.94%and 20.51%respectively,which were lower than those in negative groups(40.63%,56.00%,P<0.05).Conclusion The expressions of CXCL10 and LPA proteins are up-regulated in ovarian cancer tissues.There are differences in the expressions of CXCL10 and LPA proteins among ovarian cancer patients with different clinical characteristics,and the two indexes are both related to prognosis.