干燥综合征治疗药物研究进展

Research progress in drugs for treatment of Sjögren's syndrome

干燥综合征(Sjögren's sydrome,SS)是一种累及全身外分泌腺的自身免疫性疾病,其特征为淋巴细胞浸润唾液腺、泪腺等外分泌腺体,致腺体分泌不足,临床表现主要为口干、眼干,还可侵犯呼吸系统、消化系统等,影响患者生存质量,甚至威胁生命。SS发病机制尚未明确,目前治疗仅以对症处理为主。现综述近年来相关治疗药物,旨在为临床提供一定参考。

Sjögren's syndrome(SS)is an autoimmune disease involving exocrine glands of the whole body.It is characterized by the infiltration of lymphocytes into exocrine glands such as salivary glands and lacrimal glands,resulting in insufficient secretion of the glands.The clinical manifestations are mainly dry mouth and dry eyes,and can also invade the respiratory system and digestive system,thus affecting the quality of life of patients and even life-threatening.The pathogenesis of SS is not yet clear.At present,symptomatic treatment is the main treatment.This article reviewed related drugs in recent years,aiming to provide some reference for clinical practice.