基于德尔菲法构建多发性骨髓瘤治疗药物选择的评价指标体系

The evaluation index system of drug selection for multiple myeloma based on Delphi method

目的构建治疗多发性骨髓瘤(multiple myeloma,MM)药物合理应用的评价指标体系。方法应用德尔菲法进行专家咨询,选取30名专家进行两轮专家咨询,收集专家意见,并对结果进行统计。分析被问询专家的基本信息和问卷结果,计算积极系数、均分、满分比、变异系数及权重值等。结果构建治疗MM药物的合理应用评价指标包括一级指标6项和二级指标36项。专家问卷有效回收率均为100%,权威系数为0.86,协调系数0.293,经检验具有统计学意义(P<0.001)。结论专家积极性高,权威性和协调性好,构建的MM药物评价体系客观、合理,可为MM治疗的药物选择提供可量化的评价。

Objective To establish an evaluation index system for the rational use of drugs in the treatment of multiple myeloma(MM).Methods A total of 30 experts were selected for two rounds of expert consultation by Delphi method.The opinions of experts were collected and the results were statistically analyzed.The basic information and questionnaire results of the questioned experts were analyzed,and the positive coefficient,average score,full score ratio,coefficient of variation and weight value were calculated.Results The evaluation indexes of rational use of MM drugs included 6 primary indexes and 36 secondary indexes.The effective recovery rate of the expert questionnaire was 100%,the authority coefficient was 0.86,and the coordination coefficient was 0.293,which had statistical significance(P<0.001).Conclusion The experts are highly motivated,authoritative and coordinated,and the evaluation system of MM is objective and reasonable,which can provide quantifiable evaluation for MM drug selection.