从法尼酯X受体探讨女子以肝为先天理论与乳腺癌发病的关系

Relationship between Liver as Congenital Theory and Breast Cancer in Women from Farnyl X Receptor

当代常见的女性恶性肿瘤之一就是乳腺癌,这一疾病严重地威胁了女性的身心健康。肝脏在乳腺癌的疾病发病中具有重要的作用,“女子以肝为先天”这一论述在清代中医名著《临证指南医案》中曾被明确提出,在中医基础理论中,肝脏为疏泄和藏血重要脏器,因而情志失调常引起肝之疏泄失调,进而导致人身气机之郁结不畅,肝气不舒又致血行不畅,乳络闭阻,日久疾病发生。法尼酯X受体是以胆汁酸为配体的孤儿核受体,主要分布在肝内和胃肠道内。近年来,多项研究表明法尼酯X受体在乳腺癌的发病及远期预后中具有重要作用。在女子以肝为先天的理论基础,探讨法尼酯X受体与乳腺癌发病的关系为临床提供更多治疗乳腺癌的思路。

One of the common female malignancies in modern times is breast cancer,which seriously threatens women's physical and mental health.The liver plays an important role in the onset of breast cancer diseases,and the discussion that“women take the liver as a congenital”has been clearly proposed in the Qing Dynasty Chinese medicine masterpiece Medical Records for Clinical Guidance.In the basic theory of traditional Chinese medicine,the liver is an important organ for soothing and storing blood,so emotional disorders often cause liver failing to soothe,which in turn leads to Qi stagnation,uncomfortable liver Qi can cause poor blood flow,breast collateral obstruction and long-term diseases.Farnes ester X receptors are orphan nuclear receptors with bile acids as ligands,mainly distributed in the liver and gastrointestinal tract.In recent years,a number of studies have shown that farnimate X receptor plays an important role in the onset and long-term prognosis of breast cancer.Under the theoretical basis of women's liver as the innate theory,the relationship between farnimate X receptor and the incidence of breast cancer is explored to provide more ideas for the clinical treatment of breast cancer.