七味白术散合防己黄芪汤加减对脾虚湿阻证单纯性肥胖儿肠道菌群、体成分的影响

Effect of Qiwei Baizhu Powder(七味白术散)and Fangji Huangqi Decoction(防己黄芪汤)on Intestinal Bacterial Flora and Body Composition in Children with Simple Obesity of Spleen Deficiency and Dampness Obstruction Syndrome

目的研究七味白术散合防己黄芪汤加减对脾虚湿阻证单纯性肥胖儿肠道菌群、体成分的影响。方法选取医院2022年4月—2022年9月收治的60例脾虚湿阻证单纯性肥胖儿童作为研究对象。采用随机数字表法分为实验组(30例)和对照组(30例)。对照组给予常规治疗,实验组在对照组基础上给予七味白术散合防己黄芪汤加减治疗,两组患儿均治疗2周。比较两组患儿临床疗效以及治疗前后中医证候积分、肠道菌群、体成分(体质量、脂肪、BMI、肌肉、体脂率、无机盐和蛋白质)、血脂[总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)]。结果与对照组临床总有效率80.00%(24/30)相比,实验组96.66%(29/30)显著更高(P<0.05);两组患儿治疗后肥胖浮肿、疲倦乏力和肢体沉重积分,且与对照组相比,实验组患儿显著更低(P<0.05);两组患儿治疗后直肠真杆菌、多形拟杆菌、双歧杆菌和乳酸菌显著升高,且与对照组相比,实验组显著更高;两组患儿治疗后体质量、脂肪、BMI和体脂率显著降低,且与对照组相比,实验组更低(P<0.05);两组患儿治疗后TC、TG和LDL-C水平均显著降低,且与对照组相比,实验组更低(P<0.05)。结论七味白术散合防己黄芪汤加减对于脾虚湿阻证单纯性肥胖儿的临床疗效较高,可明显改善患儿的症状、肠道菌群和体成分。

Objective To study the effect of Qiwei Baizhu Powder(七味白术散)and Fangji Huangqi Decoction(防己黄芪汤)on intestinal bacterial flora and body composition in children with simple obesity of spleen deficiency and dampness obstruc⁃tion syndrome.Methods Sixty children with simple obesity of spleen deficiency and dampness obstruction syndrome in the hospi⁃tal from April 2022 and September 2022 were enrolled and classified into two groups by random number table methods,each with 30 cases.The control group received the routine treatment.Based on this,the experimental group received Qiwei Baizhu Powder and Fangji Huangqi Decoction.The treatment in both groups lasted for 2 weeks.Then the comparison was conducted on clinical efficacy,TCM syndrome score,intestinal bacterial flora,body composition[body weight,body fat content,body mass index(BMI),skeletal muscle mass,body fat percentage,inorganic salt content,protein content],and blood lipid parameters[total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)].Results The total efficacy rate was 96.66%(29/30)in the experimental group,which was higher than 80.00%(24/30)in control group,with statistical difference(P<0.05).After treatment,a decrease was observed in the scores of symptoms including the obesity,edema,fatigue and limb weight(P<0.05),and the decrease was more notable in the experimental group than that in the control group(P<0.05).An increase in the proportion of Eubacterium rectale,Bacteroides thetaiotaomicron,Bifidobacteria and Lactobacillus was detected in both groups after treatment(P<0.05)and the experimental group had remarkably larger proportion compared with control group,with statisti⁃cal difference(P<0.05).The body weight,body fat content,body mass index(BMI)and body fat percentage were decreased in both groups after treatment(P<0.05),and the above four parameters in experimental group were obviously lower than those in control group(P<0.05).The levels of triglyceride(TC),total cholestasis(TG)and low density lipoprotein cholesterol(LDL-C)were decreased in both groups after treatment(P<0.05),and the three blood lipid parameters of the experimental group were lower than those of the control group(P<0.05).Conclusion Application of Qiwei Baizhu Powder and Fangji Huangqi Decoction in the treatment of simple obesity of spleen deficiency and dampness obstruction syndrome can effectively ameliorate the clinical symptoms,intestinal bacterial flora and body composition in children.