培元解痉汤结合调神畅志安眠法针刺治疗帕金森病伴失眠疗效观察

Clinical Effect of Peiyuan Jiejing Decoction(培元解痉汤)Combined with Acupuncture for Regulating Spirit,Invigorating Mind and Calming Sleep on Parkinson's Disease with Insomnia

目的评估培元解痉汤结合调神畅志安眠法针刺治疗帕金森病伴失眠临床疗效。方法纳入102例帕金森病伴失眠患者(2020年2月—2022年6月收治)进行研究,将患者以随机数字表法分为两组,对照组与观察组,各51例,对照组患者采取常规治疗,观察组常规治疗+培元解痉汤结合调神畅志安眠法针刺治疗,数据观察:临床疗效、治疗前后患者中医症状总积分变化与匹兹堡睡眠质量指数量表(PSQI)评分变化、焦虑自评量表(SAS)与抑郁自评量表(SDS)评分变化、帕金森评定第二分量表(UPDRSⅡ)与第三分量表(UPDRSⅢ)评分变化、39项帕金森病生存质量调查问卷(PDQ-39)评分变化、不良反应。结果观察组患者与对照组治疗总有效率比较(96.08%VS82.35%),P<0.05;治疗前,各组患者中医症状总积分、PSQI评分、SAS与SDS评分、UPDRSⅡ与UPDRSⅢ评分、PDQ-39评分比较,P>0.05,治疗后各组患者中医症状总积分、PSQI评分、SAS与SDS评分、UPDRSⅡ与UPDRSⅢ评分、PDQ-39评分均改善,观察组患者治疗后中医症状总积分、PSQI评分、SAS与SDS评分、UPDRSⅡ与UPDRSⅢ评分、PDQ-39评分等指标优于对照组,P<0.05;两组均未见严重不良反应情况。结论培元解痉汤结合调神畅志安眠法针刺治疗帕金森病伴失眠临床疗效显著,患者睡眠质量显著改善,症状消失,恢复较好,且患者运动功能及生活质量均提升,无不良反应,安全可靠,值得应用。

Objective To evaluate the clinical efficacy of Peiyuan Jiejing Decoction(培元解痉汤)combined with acupuncture for regulating spirit,invigorating mind and calming sleep in the treatment of Parkinson's disease with insomnia.Methods A total of 102 patients with Parkinson's disease associated with insomnia(February 2020—June 2022)in this study were selected and di⁃vided into two groups by the random number table method,51 cases in each group.The control group adopted regular treatment and the observation group used routine treatment and Peiyuan Jiejing Decoction combined with acupuncture for regulating spirit,invigorating mind and calming sleep.The clinical curative effect and the total scores of TCM symptoms in patients,Pittsburgh sleep quality index scale(PSQI)scores,self-evaluation of anxiety scale(SAS)and depression self rating scale(SDS)scores,the second scale(UPDRSⅡ)of Parkinson's disease evaluation and the third scale(UPDRSⅢ)scores,39 items questionnaire of qual⁃ity of life of Parkinson's disease(PDQ-39)scores before and after treatment and adverse reactions were compared.Results The total effective rates of the observation group and the control group were 96.08%and 82.35%,respectively(P<0.05).Before treatment,the total scores of TCM symptoms,PSQI score,SAS and SDS scores,UPDRSⅡand UPDRSⅢscores and PDQ-39 score of patients in each group were not significant(P>0.05).After treatment,the total scores of TCM symptoms,PSQI score,SAS and SDS scores,UPDRSⅡand UPDRSⅢscores and PDQ-39 score were improved in both groups.After treatment,the to⁃tal scores of TCM symptoms,PSQI score,SAS and SDS scores,UPDRSⅡand UPDRSⅢscores and PDQ-39 score of the obser⁃vation group were better than those of the control group(P<0.05).No serious adverse reactions were observed in the two groups.Conclusion Peiyuan Jiejing Decoction combined with acupuncture for regulating spirit,invigorating mind and calming sleep in the treatment of Parkinson's disease with insomnia has a significant clinical effect.The patients'sleep quality has signifi⁃cantly improved,symptoms have disappeared,and recovery is good.The patient's motor function and quality of life have also im⁃proved,and there are no adverse reactions.It is safe and reliable,and is worthy of application.