芬顿反应在化学动力学治疗中的应用

The application of Fenton reaction in chemodynamic therapy

肿瘤微环境H_(2)O_(2)含量不足、p H值不适合、还原性物质含量过高及反应催化剂效率低等原因,导致传统的芬顿反应(Fe^(2+)+H_(2)O_(2)→Fe^(3+)+·OH)在癌症治疗中效率较低,限制了通过芬顿反应产生羟基自由基来进行肿瘤特异性治疗的化学动力学治疗(chemodynamic therapy,CDT)在活体治疗中的应用.可以通过优化芬顿及类芬顿反应催化剂体系、调节肿瘤微环境、增强催化剂效率和协同治疗的方法提高CDT的治疗效率.

Chemodynamic therapy(CDT)is to produce hydroxyl radicals through the Fenton reaction(Fe^(2+)+H_(2)O_(2)→Fe^(3+)+·OH)for tumor-specific treatment.However,the low efficiency of traditional Fenton reaction in cancer treatment limits the application of CDT in vivo treatment.The reasons for the low efficiency of Fenton re⁃action include insufficient H_(2)O_(2)content in tumor microenvironment,unsuitable pH,high content of reducing substances and low efficiency of reaction catalyst.The results show that the treatment efficiency of CDT can be improved by optimizing the Fenton and Fenton-like reaction catalyst system,regulating the tumor microenvi⁃ronment,enhancing the catalyst efficiency and synergistic therapy.