摘要
在骨组织工程领域,通过物理刺激形成生物信号来调控间充质干细胞的增殖和定向分化是最简单、有效的方式。静电纺丝技术是制造纳米纤维支架较理想的技术之一,通过静电纺丝技术制成的纳米纤维可以模拟出近似细胞外基质的纳米结构,促进间充质干细胞的增殖及分化。本文综述了近年来静电纺丝纳米拓扑结构的发展及对间充质干细胞成骨分化的影响。
In the field of bone tissue engineering,regulating the proliferation and directed differentiation of mesenchymal stem cells through physical stimulation to form biological signals is the simplest and most effective method.Electrospinning technology is one of the ideal technologies for manufacturing nanofiber scaffolds.The nanofibers produced by electrospinning technology can simulate the nanostructure similar to the extracellular matrix,promoting the proliferation and differentiation of mesenchymal stem cells.This article reviews the development of electrospinning nanofiber topology in recent years and its impact on the osteogenic differentiation of mesenchymal stem cells.
作者
王莉莉
刘更
田园园
WANG Li-li;LIU Geng;TIAN Yuan-yuan(Tianjin Stomatological Hospital Department of Prosthodontics;Hospitalof Stomatology,Nankai University,Tianjin 300041,China)
出处
《口腔颌面修复学杂志》
2024年第1期75-80,共6页
Chinese Journal of Prosthodontics
基金
天津市卫生健康科技项目(项目编号:ZC20040)。
关键词
静电纺丝
纳米拓扑结构
间充质干细胞
骨组织工程
electrospinning
nanofiber topology
mesenchymal stem cells
bone tissue engineering
