色素增加性皮肤病患者治疗中激光与中医药联合应用研究

A Study on the Combined Application of Laser and Traditional Chinese Medicine in the Treatment of Pigmented Skin Disease Patients

目的探讨激光联合中医药治疗色素增加性皮肤病的临床效果,为临床研究提供参考。方法选取2019年1月—2022年1月滨州医学院附属医院收治的78例色素增加性皮肤病患者作为研究对象,依据随机数表法将所有患者分为参照组和研究组,每组39例。参照组采用激光治疗,研究组在参照组治疗基础上联合中医药治疗,统计并分析两组患者治疗前后皮肤生理指标[pH、角质层含水量、皮肤经水分丢失(TWEL)]、性激素水平[雌二醇(E2)、黄体生成素(LH)、促卵泡生成素(FSH)、孕酮(Pro)]、色素沉着面积、色素沉着评分改善状况,皮肤的结痂、愈合时间与痂皮脱落时间、治疗总有效率和不良反应发生率。结果治疗前组间角质层含水量、pH、TWEL指标、E2、Pro、LH、FSH水平、色素沉着评分、色素沉着面积及治疗后pH比较,差异无统计学意义(P>0.05),但研究组治疗后的TWEL指标、LH、E2、Pro、FSH水平、色素沉着评分和不良反应发生率均比参照组低,角质层含水量、治疗总有效率高于参照组,且色素沉着面积较参照组小,差异有统计学意义(P<0.05)。结论色素增加性皮肤病患者采用激光联合中医药治疗,不但可以增强皮肤屏障功能,降低患者性激素水平,还能有效避免皮肤色素沉重,加快皮肤结痂、愈合,有效提升治疗效果,且不良反应较少,提高患者的治疗安全性,具有显著的临床疗效,值得临床应用。

Objective Discuss the laser treatment combined with traditional Chinese medicine pigment increased sexual pigment to increase the clinical effect of skin,provide reference for clinical research.Methods 78 patients with hyperpigmentation skin disease admitted to the Affiliated Hospital of Binzhou Medical College from January 2019 to January 2022 were selected as the research subjects.All patients were divided into a reference group and a study group using a random number table method,each group 39 cases.Reference group with laser therapy,the team on the basis of the combined treatment of traditional Chinese medicine,statistics and analysis of two groups before and after treatment in patients with the skin physiology index[pH,corneous layer water content,skin moisture loss(TWEL)],sex hormone levels[estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH),progesterone(Pro)],pigmentation area,pigmentation improve performance ratings,skin crusting,healing time and scab skin peeling time,total effective rate and incidence of adverse reactions.Results Before treatment between groups corneous layer water content,pH value,TWEL index,pigmentation score,pigmentation area and pH value comparison after treatment and no significant difference(P>0.05),but the team after treatment of TWEL index,pigmentation rate and incidence of adverse reactions are lower than the control group,corneous layer water content,total effective rate was higher than control group,and pigmentation area is smaller than control group,data compared with significant difference(P<0.05).Conclusion Pigment increased sex skin disease were treated by laser treatment combined with traditional Chinese medicine,not only can strengthen the skin barrier function,reduce the patients with sex hormone levels,also can effectively avoid skin pigment,heavy can accelerate skin crusting,healing,can effectively improve the treatment effect,and less adverse reaction,can guarantee safety of the treatment of patients with significant clinical curative effect,suitable for clinical applications.