阿尔茨海默病患者嗅觉相关磁共振研究进展

Advancements in Olfactor y Related Magnetic Resonance Imaging in Patients with Alzheimer's Disease

阿尔茨海默病(Alzheimer's disease,AD)是痴呆症的最常见形式,早期发现并干预是推迟或避免AD病理进展以及提高患者生活质量的关键。嗅觉障碍是AD患者最常见的临床症状之一,且早于认知障碍出现,因此嗅觉障碍筛查可能有助于早期发现并诊断AD。磁共振成像作为无创性的成像技术,被广泛应用于AD患者嗅觉相关研究。本文就AD患者嗅觉相关结构磁共振研究、弥散张量成像研究、静息态功能磁共振及任务态功能磁共振研究进展进行综述。

Alzheimer's disease(AD)is the most common type of dementia,and early detection and intervention are critical for delaying or minimizing the pathological development of AD and improving the quality of life of patients.Olfactory dysfunction is one of the most common clinical symptoms in AD patients,and it occurs earlier than cognitive impairment.Therefore,olfactory dysfunction screening may be helpful for early detection and diagnosis of AD.Magnetic resonance imaging,as a non-invasive imaging technique,is widely used in olfactory related research in AD patients.This article provides a review of the research progress on olfactory related structural magnetic resonance imaging,diffusion tensor imaging,resting state functional magnetic resonance imaging,and task state functional magnetic resonance imaging in AD patients.