泛凋亡在青光眼发病机制和治疗中的研究进展

Research progress of PANoptosis in the mechanism and treatment of glaucoma

青光眼是一组以进行性视网膜神经节细胞(retinal ganglion cells,RGC)丢失及轴突损伤为特征的不可逆性致盲性眼病,其损伤机制尚未阐明。泛凋亡是一种炎性细胞死亡途径,包括细胞凋亡、坏死性凋亡和细胞焦亡三种细胞程序性死亡。在青光眼患者视网膜及青光眼实验动物模型中存在着三种细胞死亡途径的激活及分子间的相互串扰,与青光眼RGC死亡的发生发展密切相关,并且靶向干预泛凋亡相关分子可抑制青光眼视网膜损伤和RGC丢失。

Glaucoma is a group of irreversible blinding ophthalmopathies characterized by progressive loss of retinal ganglion cells(RGC)and axonal damage.The specific damage mechanism has not been clarified.PANoptosis is an inflammatory cell death pathway,including apoptosis,necroptosis and pyroptosis.There are three activation pathways of cell death and molecular crosstalk in the retina of glaucoma patients and experimental animal models of glaucoma,which are closely related to the occurrence and development of glaucomatous RGC death.Targeted intervention with PANoptotic related molecules can inhibit retinal damage and RGC loss in glaucoma.