中文版胰腺炎生活质量评估量表在慢性胰腺炎患者中的应用评价

Application evaluation of Chinese version of the pancreatitis quality of life instrument in chronic pancreatitis patients

目的基于中文版胰腺炎生活质量评估量表(PANQOLI)评估我国CP患者的生活质量水平及其影响因素。方法选取2021年9月至2022年1月间海军军医大学第一附属医院消化内科404例CP住院患者为研究对象,使用中文版PANQOLI量表对CP患者生活质量进行评估,采用单因素和多元线性回归分析影响CP患者生活质量的因素。结果404例CP患者的生活质量总评分为28~94(72.47±13.61)分,相较中文版PANQOLI最高总分103分下降了29.64%。其中身体功能、角色功能、情绪功能、自我价值分别为(25.63±4.84)、(13.86±2.78)、(16.98±6.21)、(16.00±4.65)分,相较中文版PANQOLI各子量表最高分30、25、24、24分别下降了14.57%、44.56%、29.25%、33.33%。单因素分析结果显示,性别、年龄、职业、吸烟情况、饮酒情况、胰腺炎复发次数显著影响CP患者生活质量;多元线性分析结果表明,高龄(r=-0.127)、失业(r=-0.106)、吸烟(r=-0.176)和胰腺炎反复发作(r=-0.123)是CP患者生活质量的独立影响因素(P值均<0.05)。结论中文版PANQOLI量表可有效应用于我国CP患者,高龄、失业、吸烟和胰腺炎发作是影响CP患者生活质量的危险因素,可据此制定个性化的干预措施以改善CP患者生活质量。

Objective To evaluate the quality of life(QoL)of Chinese chronic pancreatitis(CP)patients based on the Chinese version of the pancreatitis quality of life Instrument(PANQOLI)and explore its impact factors.Methods 404 patients with CP admitted to the Department of Gastroenterology of the First Affiliated Hospital of Naval Medical University between September 2021 and January 2022 were enrolled.The Chinese version of PANQOLI was used for questionnaire survey on QoL of CP patients.Univariate analysis and multiple linear regression analysis were used to explore the impact factors for QoL of CP patients.Results The total score of QoL of 404 Chinese CP patients was 28-94(72.47±13.61),which declined by 29.64%compared to the highest total score(103)in the Chinese version of PANQOLI.Score of physical function,role function,emotional function,and self-worth domain was 25.63±4.84,13.86±2.78,16.98±6.21 and 16.00±4.65,respectively.Compared to the highest scores(30,25,24 and 24),the scores of aforementioned four domains declined by 14.57%,44.56%,29.25%and 33.33%,respectively.Univariate analysis showed that sex,age,employment status,smoking,alcohol consumption,and frequency of pancreatitis recurrence were significantly associated with QoL of CP patients.Multiple linear regression analysis indicated that older age(coefficient=-0.127),unemployment status(coefficient=-0.106),smoking(coefficient=-0.176),and high frequency of pancreatitis recurrence(coefficient=-0.123)were independent factors for QoL of CP patients(all P value<0.05).Conclusions The Chinese version of PANQOLI could be effectively applied to Chinese CP patients.Older age,unemployment,smoking,and pancreatitis attacks were risk factors for QoL of CP patients,indicating that the formulation of personalized intervention measures may help to improve QoL of CP patients.