阻塞性睡眠呼吸暂停与乳腺癌相关性研究进展

Advances in research on the relationship between obstructive sleep apnea and breast cancer

动物实验结果表明,阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)所致间歇低氧是乳腺癌发生的危险因素。尽管存在生物合理性,但过去多项临床流行病学研究结果却并不一致。不过,近年发表的一项包括7个大型研究、共5 370 466例患者的荟萃分析结果显示,与无OSA患者相比,OSA患者发生乳腺癌的风险增加36%(HR 1.36,95%CI 1.03~1.80)。论文对此进行介绍,包括临床流行病学研究结果以及可能的发病机制。

Animal studies suggest that intermittent hypoxia due to obstructive sleep apnea(OSA)is a risk factor for breast cancer.Despite biological plausibility,human epidemiological studies have shown inconsistent results.However,a recent meta-analysis of seven large studies with a total of 5370466 patients showed that patients with OSA had a 36%increased risk of breast cancer compared to patients without OSA(HR 1.36,95%CI 1.03-1.80).This article reviews the research on the relationship between OSA and breast cancer,including the possible pathogenesis of OSA-associated breast cancer.