口咽运动治疗成人阻塞性睡眠呼吸暂停低通气综合征的疗效初步观察

Observation on the therapeutic effect of oropharyngeal exercise on adult obstructive sleep apnea hypopnea syndrome

目的 观察口咽运动对成人阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome, OSAHS)治疗效果。方法 随机将满足OSAHS诊断以及纳入条件的成人60例患者分到实验组和对照组中,实验组分为颏舌肌组、单纯软腭组、非颏舌肌组,实验组的患者进行改变咽腔变化的咽部肌肉训练12周,对照组的患者进行不改变咽腔变化的口咽运动训练12周。分别收集了患者于治疗前、治疗12周后多导睡眠检测指标。运用统计学软件对相关指标进行疗效差异性统计。结果 各实验组和对照组中患者的年龄、性别、体质量指数比较结果差异无统计学意义(P=0.201、0.439、0.816、0.326、0.294),具有可比性。治疗效果比较结果各组复查呼吸暂停低通气指数(apnea-hypopnea index, AHI)较治疗前均降低,且差异有统计学意义(P=0.005、<0.001、0.003、0.001)。4组复查最低血氧饱和度较治疗前均升高,且比较结果存在统计学差异(P=0.019、0.020、0.001、0.001)。实验组和对照组对AHI及最低血氧饱和度的影响差异无统计学意义(P=0.776、0.770)。结论 对照组及实验组口咽运动方式对OSAHS患者的治疗均有帮助,各组之间差异无统计学意义。

Objective This study aimed to observe the therapeutic effect of oropharyngeal exercise on adult obstructive sleep apnea hypopnea syndrome(OSAHS).Methods Sixty adult patients who met the diagnosis and inclusion criteria of OSAHS were randomly divided into the experimental and control groups.The experimental group was divided into the genioglossus,soft palate,and non-genioglossus groups and received pharyngeal muscle training with changes in the pharyngeal cavity for 12 weeks.The control group received oropharyngeal exercise training without changing the pharyngeal cavity for 12 weeks.The polysomnography indexes were collected before treatment and 12 weeks after treatment.Statistical software was used to analyze the difference of the curative effect of related indexes.Results There was no significant difference in the age,sex,and body mass index between the experimental and control groups(P=0.201,0.439,0.816,0.326,0.294).In the comparison of treatment effects,the apnea-hypopnea index(AHI)of each group was lower than that before treatment,and the difference was statistically significant(P=0.005,<0.001,0.003,0.001).The lowest oxygen saturation in the four groups was higher than that before treatment,and there was a significant difference between the four groups(P=0.019,0.020,0.001,0.001).There was no significant difference in AHI and lowest oxygen saturation between the experimental and control groups(P=0.776,0.770).Conclusion The mode of oropharyngeal exercise in the control and experimental groups is helpful in treating patients with OSAHS,and there is no significant difference among the four groups.