中医辨证施治胆管癌用药规律及药理学研究进展

Research progress on medication patterns and pharmacology of traditional Chinese medicine for treating cholangiocarcinoma based on syndrome differentiation

胆管癌是由胆汁淤积、胆管结石、肝硬化、自身免疫性肝病、肝炎等前置病变恶化发展而来的重大疾病。通过对临床诊疗中常见的5种胆管癌中医证型进行总结,分析各证型胆管癌的临床常用方药。通过频次与用药规律分析,筛选出关键中药,并根据其功效归纳为疏肝健脾、清热祛湿与其他功效中药,并从现代药理学角度总结了相关研究进展。通过系统梳理胆管癌辨证论治的用药规律,为胆管癌临床诊疗和抗胆管癌中药创新药物研发提供参考。

Cholangiocarcinoma is a major disease that results from the progression of pre-existing lesions including cholestasis,bile duct stones,cirrhosis,autoimmune liver disease,and hepatitis.This paper summarizes the five common traditional Chinese medicine(TCM)syndrome types of cholangiocarcinoma in clinical diagnosis and treatment,and then analyzes the most commonly used clinical prescriptions for each syndrome type.Based on analysis of frequency and compatibility of medicines,key herbal products are selected and categorized into three parts:harmonizing liver and invigorating spleen medicines,clearing heat and eliminating dampness medicines,and medicines with other effects.Additionally,the paper summarizes relevant research progress from a pharmacological perspective.This paper systematically sorts out the compatibility of medicines for TCM syndrome differentiation and treatment of cholangiocarcinoma,serving as a reference for clinical diagnosis and treatment of cholangiocarcinoma,as well as for the development of innovative TCM for the treatment of cholangiocarcinoma.