摘要
胶原蛋白水凝胶是一种新型创面敷料,胶原蛋白和水凝胶的优势相结合,可有效发挥二者各自在创面修复再生中的优势。近年来,利用物理和化学的手段对胶原蛋白水凝胶的机械特性和生物功能等进行完善,使其更适用于创面环境,已成为科研与临床的研究热点。该文系统回顾了胶原蛋白水凝胶在创面修复中的理论基础、应用现状和研究进展,分析了其当前的优势、局限及未来的研究方向,以期为胶原蛋白水凝胶的研制及其在创面修复领域的临床应用提供参考和新的思路。
Collagen hydrogel is a new type of wound dressing.The combination of the advantages of collagen and hydrogel can effectively exert their respective advantages in wound repair and regeneration.In recent years,the use of physical and chemical method to improve the mechanical properties and biological functions of collagen hydrogels to make them more suitable for wound environment has become a hotspot in scientific research and clinical trials.This review systematically summarized the theoretical basis,application status and research progress of collagen hydrogel in wound repair,and analyzed the current advantages,limitations,and future research directions,to provide reference and directions for the development of collagen hydrogel and its clinical application in the field of wound repair.
作者
程宇欣
左扬清
孔维诗
孙瑜
Cheng Yuxin;Zuo Yangqing;Kong Weishi;Sun Yu(School of Basic Medicine,Naval Medical University,Shanghai 200433,China;Department of Burn Surgery,the First Affiliated Hospital of Naval Medical University,Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury,Chinese Academy of Medical Sciences,Shanghai 200433,China)
出处
《中华整形外科杂志》
CSCD
2023年第12期1371-1376,共6页
Chinese Journal of Plastic Surgery
基金
国家重点研发计划资助(2019YFA0110600,2019YFA0110602,2019YFA0110603)。
关键词
胶原
水凝胶类
生物敷料
创面修复
Collagen
Hydrogels
Biological dressings
Wound repair
