高血压与骨质疏松症相关机制研究进展

Research progress on the correlation mechanism between hypertension and osteoporosis

高血压和骨质疏松症是两种常见的年龄相关疾病,发病率正在逐渐增加,研究表明,这两种疾病之间存在一定的相关性。除了不可控的遗传因素外,高血压环境中的高钠饮食、血管中活性氧的增加、细胞因子、肾素-血管紧张素-醛固酮系统也影响了骨代谢,同时破骨细胞、骨保护素对血压的影响以及已被证明导致骨质疏松症的钙及维生素D的缺乏也参与了高血压的形成。总结两种疾病的可能相关机制,以期拓展临床防治思路。

Hypertension and osteoporosis are two common age-related diseases,and the incidence rate is gradually increasing.Research shows that there is a certain correlation between these two diseases.In addition to uncontrolled genetic factors,factors in the hypertensive environment including high sodium in the diet,the increase of reactive oxygen species in blood vessels,cytokines,renin angiotensin aldosterone system,which also affect bone metabolism.At the same time,the influence of osteoclasts and osteoprotegerin on blood pressure and the lack of calcium and vitamin D that have been proved to lead to osteoporosis are also involved in the formation of hypertension.By summariz-ing the possible related mechanisms of the two diseases,we hope to expand the ideas of clinical prevention and treatment.