摘要
亚临床甲状腺功能减退症(SCH)是老年人常见疾病之一。促甲状腺激素(TSH)的正常切点受年龄、碘营养状况等多种因素影响,显著影响了老年SCH的诊断和治疗。心血管疾病是老年SCH的主要终点事件,应根据TSH水平、年龄和心血管疾病及其危险因素指导老年SCH的干预。对于老年SCH患者是否需要进行左甲状腺素替代治疗,尤其是TSH在10~20 mU/L的这部分群体,替代治疗能否获益,尚需前瞻性的干预研究进行证实。
Subclinical hypothyroidism(SCH)is one of the common diseases in the elderly.The normal cut-off point for thyroid stimulating hormone(TSH)is influenced by a variety of factors,including age and iodine nutritional status,which significantly affects the diagnosis and treatment of SCH in the elderly.Cardiovascular disease is the major endpoint event of SCH in the elderly,and interventions for SCH in the elderly should be guided by TSH levels,age,and cardiovascular disease and its risk factors.Prospective intervention studies are needed to confirm the need for levothyroxin replacement therapy in elderly SCH patients,especially in this group with TSH in the range of 10-20 mU/L,and whether replacement therapy can be beneficial.
作者
孙宇
王艳
徐书杭
刘超
Sun Yu;Wang Yan;Xu Shuhang;Liu Chao(Department of Endocrinology and Metabolism,the Affiliated Suqian Hospital of Xuzhou Medical University,Suqian 223800,China;Department of Geriatrics,the Affiliated Suqian Hospital of Xuzhou Medical University,Suqian 223800,China;Department of Endocrinology and Metabolism,Affiliated Hospital of Integration Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine,Nanjing 210028,China)
出处
《国际内分泌代谢杂志》
2023年第6期521-524,共4页
International Journal of Endocrinology and Metabolism
基金
2020年江苏省重点研发计划(BE2020726)
2021年江苏省老年健康科研项目(LK2021059)。
关键词
老年人
亚临床功能减退症
心血管疾病
甲状腺激素替代治疗
Elderly
Subclinical hypothyroidism
Cardiovascular disease
Thyroid hormone replacement therapy
