艾司奥美拉唑钠持续泵入与静脉滴注给药方式在消化性溃疡合并出血患者中的应用效果

Application effect of continuous pumping and intravenous infusion of esomeprazole sodium in patients with peptic ulcer complicated with hemorrhage

目的 比较艾司奥美拉唑钠持续泵入与静脉滴注给药方式在消化性溃疡合并出血患者中的应用效果。方法 选择2018年4月至2021年4月收治的90例消化性溃疡合并出血患者作为研究对象,按红绿双色球法将其分为对照组和研究组,各45例。对照组给予艾司奥美拉唑钠静脉滴注治疗,研究组给予艾司奥美拉唑钠持续泵入治疗。比较两组的治疗效果。结果 研究组的出血、呕血、黑便停止时间和腹痛缓解时间短于对照组(P<0.05)。研究组的治疗总有效率为95.56%,显著高于对照组的80.00%(P<0.05)。治疗后,研究组的纤维蛋白原、D-二聚体水平低于对照组,血小板计数(PLT)、红细胞比容(HCT)高于对照组(P<0.05)。治疗后,研究组的表皮生长因子(EGF)、前列腺素E2(PGE2)水平高于对照组,基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-3(MMP-3)水平低于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 相比于艾司奥美拉唑钠静脉滴注给药,持续泵入效果会更好,能够缩短消化性溃疡合并出血患者临床症状消失时间,提高治疗效果,改善凝血功能及血清指标。

Objective To compare the application effect of continuous pumping and intravenous infusion of esomeprazole sodium in patients with peptic ulcer complicated with hemorrhage.Methods A total of 90 patients with peptic ulcer complicated with hemorrhage admitted from April 2018 to April 2021 were selected as the research objects and divided into control group and study group according to the red and green double chromosphere method,with 45 cases in each group.The control group was treated with intravenous infusion of esomeprazole sodium,and the study group was treated with continuous pumping of esomeprazole sodium.The therapeutic effects of the two groups were compared.Results The stop time of bleeding,hematemesis,melena stop time and abdominal pain relief time of the study group were shorter than those of the control group(P<0.05).The total effective rate of treatment in the study group was 95.56%,which was significantly higher than 80.00%in the control group(P<0.05).After treatment,the levels of fibrinogen and D-dimer in the study group were lower than those in the control group,and the platelet count(PLT)and hematocrit(HCT)were higher than those in the control group(P<0.05).After treatment,the levels of epidermal growth factor(EGF)and prostaglandin E2(PGE2)in the study group were higher than those in the control group,and the levels of matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-3(MMP-3)were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with the administration of intravenous infusion of esomeprazole sodium,continuous pumping has a better effect,which can shorten the disappearance time of clinical symptoms of patients with peptic ulcer complicated with hemorrhage,improve treatment effect,and improve the coagulation function and serum indexes.