HR-HPV DNA联合TCT检查在子宫颈癌前病变筛查中的应用价值

Application value of HR-HPV DNA combined with TCT in the screening of cervical precancerous lesions

目的 分析高危型人乳头瘤病毒基因(HR-HPV DNA)联合液基细胞学(TCT)检查在子宫颈癌前病变筛查中的应用价值。方法 选取2022年1月至12月于我院妇科门诊接受子宫颈癌前病变筛查的1 374例妇女作为研究对象。所有研究对象均接受TCT、HR-HPV DNA及组织病理学检查。以组织病理学检查结果为金标准,分析TCT、HR-HPV DNA单独及联合检查结果并比较诊断效能。结果 病理学检查结果显示,1 374例妇女中阳性184例,检出率为13.39%。1 374例妇女中,TCT检查检出180例阳性患者,阳性检出率为13.10%;HR-HPV DNA检查检出195例阳性患者,阳性检出率为14.19%;TCT与HR-HPV DNA联合检查检出191例阳性患者,阳性检出率为13.90%。TCT与HR-HPV DNA联合检查的诊断灵敏度、特异度、准确度、阳性预测值、阴性预测值高于HR-HPV DNA检查(P<0.05);TCT与HR-HPV DNA联合检查的诊断灵敏度、准确度、阴性预测值高于TCT检查(P<0.05);TCT、HR-HPV DNA联合检查与TCT检查的诊断特异度、阳性预测值比较,差异无统计学意义(P>0.05)。结论 HR-HPV DNA与TCT联合检查应用于子宫颈癌前病变筛查中可提高效能,为医师早期诊断提供准确参考依据,值得推广。

Objective To analyze the application value of high risk human papilloma virus DNA(HR-HPV DNA)combined with thinprep cytology test(TCT)in the screening of cervical precancerous lesions.Methods A total of 1374 women who received screening for cervical precancerous lesions in the gynecological clinic of our hospital from January to December 2022 were selected as the research objects.All research objects underwent TCT,HR-HPV DNA and histopathological examination.The results of TCT and HR-HPV DNA alone and combined examination were analyzed and the diagnostic efficacy was compared with the results of histopathological examination as the gold standard.Results The results of pathological examination showed that 184 cases of 1374 women were positive,with a detection rate of 13.39%.Among the 1374 women,180 positive patients were detected by TCT examination,and the positive detection rate was 13.10%;195 positive patients were detected by HR-HPV DNA examination,and the positive detection rate was 14.19%;191 positive patients were detected by TCT combined with HR-HPV DNA examination,and the positive detection rate was 13.90%.The diagnostic sensitivity,specificity,accuracy,positive predictive value and negative predictive value of TCT combined with HR-HPV DNA examination were higher than those of HR-HPV DNA examination(P<0.05);the diagnostic sensitivity,accuracy and negative predictive value of TCT combined with HR-HPV DNA examination were higher than those of TCT examination(P<0.05);there were no significant differences in diagnostic specificity and positive predictive value between TCT,HR-HPV DNA combined examination and TCT examination(P>0.05).Conclusion HR-HPV DNA combined with TCT examination applied in the screening of cervical precancerous lesions can improve the efficiency and provide accurate reference for the early diagnosis of doctors,which is worthy of promotion.