肝细胞癌组织微RNA-597表达与临床病理特征、肝动脉化疗栓塞术疗效的关系

Research on the relationship between miR-597 expression in hepatocellular carcinoma tissue and clinicopathological features and TACE efficacy

目的 探讨肝细胞癌组织微核糖核酸-597(miR-597)表达与临床病理特征、肝动脉化疗栓塞术(TACE)疗效的关系。方法选取2019年1月至2021年1月荆门市人民医院收治的肝细胞癌病人136例,比较不同临床病理特征病人癌组织中miR-597表达水平;另治疗后随访3个月,根据TACE疗效将病人分为有效组和无效组,并比较miR-597表达水平;采用多因素logistic回归分析影响肝细胞癌病人TACE疗效的相关因素。结果 伴门静脉癌栓、伴淋巴结转移、肿瘤长径>5 cm、Ⅲa期、低分化、Child-Pugh分级B级的肝细胞癌病人癌组织中miR-597表达水平均低于无门静脉癌栓、无淋巴结转移、肿瘤长径≤5 cm、Ⅰb+Ⅱ期、中高分化、Child-Pugh分级A级的病人(P<0.05);TACE治疗后,治疗有效率为22.06%,有效组癌组织中miR-597表达水平高于无效组(0.827±0.054比0.351±0.046,P<0.05);经logistic回归分析发现,门静脉癌栓、淋巴结转移、肿瘤长径、临床分期、病理分化、Child-Pugh分级、微血管侵犯、血清甲胎蛋白(AFP)及癌组织中miR-597表达水平均是肝细胞癌病人TACE疗效的影响因素(P<0.05)。结论 肝细胞癌组织miR-597表达水平与病人临床病理学特征密切相关,且miR-597表达水平亦与TACE疗效有关,其低表达量常提示TACE疗效不佳。

Objective To investigate the relationship between microRNA-597(miR-597)expression in hepatocellular carcinoma tis⁃sue and clinicopathological features and the efficacy of hepatic arterial chemoembolization(TACE).Methods A total of 136 patients with hepatocellular carcinoma admitted to Jingmen People's Hospital from January 2019 ro January 2021 were selected.The expres⁃sion levels of miR-597 in cancer tissues of patients with different clinicopathological features were compared.Followed up for 3 month after treatment,patients were divided into the effective group and the ineffective group according to the efficacy of TACE,and the ex⁃pression level of miR-597 was compared.Multivariate logistic regression analysis method was used to analyze the influencing factors of TACE in patients with hepatocellular carcinoma.Results The expression levels of miR-597 in cancer tissues of patients with portal vein tumor thrombus,lymph node metastasis,maximum tumor diameter>5 cm,stage IIIa,poorly differentiated,Child-Pugh grade B were lower than those of patients without portal vein tumor thrombus,lymph node metastasis,maximum tumor diameter≤5 cm,stageⅠb+Ⅱ,moderately well differentiated,Child-Pugh gradeA(P<0.05).After TACE treatment,the effective rate was 22.06%(30/136),and in the effective group the expression level of miR-597 in cancer tissues was higher than that in the ineffective group(0.827±0.054 vs.0.351±0.046,P<0.05).Logistic regression analysis showed that portal vein tumor thrombus,lymph node metastasis,maximum tumor di⁃ameter,clinical stage,pathological differentiation,Child-pugh grade,microvascular invasion,serum alpha-fetoprotein(AFP)and miR-597 expression level in cancer tissues were influencing factors for TACE efficacy in patients with hepatocellular carcinoma(P<0.05).Conclusion The expression level of miR-597 in hepatocellular carcinoma tissue is closely related to the clinical pathological charac⁃teristics of patients,and the expression level of miR-597 is also related to the efficacy of TACE,and its low expression often indicates that the efficacy of TACE is poor.