江苏省丙型肝炎病毒感染患者的病毒基因型分布特点分析

Analysis of the Distribution Characteristics of Virus Genotypes in Patients Infected with Hepatitis C Virus in Jiangsu Province

目的:分析江苏省丙型肝炎病毒(hepatitis C virus,HCV)感染患者的病毒基因型分布特点,为进一步研究HCV感染的流行情况和防治策略提供参考依据。方法:选取2020年1月—2021年5月江苏省内苏州、扬州、镇江、徐州和连云港5市共924例HCV感染患者的血清样本作为研究材料,对血样进行HCV基因分型检测,分析HCV的病毒基因型分布特点。结果:924例HCV感染患者的年龄主要集中在>50~60岁(293例,占31.71%)、>60~70岁(211例,占22.74%)和>40~50岁(137例,占14.83%)三个年龄段;924例患者的血清样本中共检出8种基因型,其中主要为1b型(697,占75.43%),其次为2a型(152,占16.45%)为主;此外,苏南(即苏州)与苏中(即扬州+镇江)、苏中与苏北(即徐州+连云港)在1b型的分布上均存在显著差异(P<0.05),而苏南、苏中、苏北在2a型的分布上两两间均存在显著差异(P<0.05)。结论:江苏省内HCV感染患者的年龄主要集中在>40~70岁,而病毒的基因型主要为1b型、其次为2a型,临床应持续重视HCV感染特点的调查研究,助力HCV感染的防治。

Objective:To analyze the distribution characteristics of virus genotypes in hepatitis C virus(HCV)in‐fected patients in Jiangsu Province,and provide a reference for further research on the prevalence and control strategies of HCV infection.Methods:Serum samples from 924 HCV infected patients in Suzhou,Yangzhou,Zhenjiang,Xuzhou,and Lianyungang of Jiangsu Province from January 2020 to May 2021 were selected as the research data,on which HCV genotype testing was performed to analyze the distribution characteristics of HCV virus genotypes.Results:The ages of 924 HCV infected patients were mainly concentrated in three age groups,namely elder than 50-60 years old(293 cases,31.71%),elder than 60-70 years old(211 cases,22.74%),and elder than 40-50 years old(137 cases,14.83%).A total of 8 genotypes were detected in serum samples from the 924 patients,with the main genotype being 1b(697,75.43%),followed by 2a(152,16.45%).In addition,there were significant differences(P<0.05)in the distribution of type 1b between southern Jiangsu(i.e.Suzhou)and central Jiangsu(i.e.Yangzhou+Zhenjiang),as well as between central Jiangsu and northern Jiangsu(i.e.Xuzhou+Lianyungang),while there were significant differences(P<0.05)in the distribution of type 2a among southern Jiangsu,central Jiangsu,and northern Jiangsu.Conclusion:The ages of HCV infected patients in Jiangsu Province are mainly concentrated in the age group of elder than 40 to 70 years old,and the genotype of the virus is mainly 1b,followed by 2a.Attention should be continuously paid to clinical research on the HCV infection characteristics to assist in the prevention and treatment of HCV infection.