白细胞介素-17家族及其基因多态性与银屑病的研究进展

Research Progress in Association of Interleukin-17 Family and Its Gene Polymorphisms with Psoriasis

银屑病的具体发病机制尚不清楚。目前认为,白细胞介素-17(IL-17)参与的炎症级联反应等与银屑病发展有关。针对IL-17的靶向药物在银屑病治疗中有一定效果,但也存在不良反应,且不同个体存在疗效差异。近年来,随着基因多态性相关研究的逐渐深入,IL-17基因多态性与银屑病的遗传易感性之间的关系被广泛研究。目前全球已开展了针对多人群的IL-17基因与银屑病患病风险密切相关的全基因组关联研究,并针对不同个体对已批准生物制剂的反应进行基因层面的分析。未来,深入研究IL-17基因多态性与银屑病的关系对银屑病的治疗有重要临床意义。

The specific pathogenesis of psoriasis is still unclear.Currently,it is believed that the inflammatory cascade involving interleukin-17(IL-17)is related to the development of psoriasis.Targeted drugs targeting IL-17 have certain effects in the treatment of psoriasis,but there are also adverse reactions,and there are differences in efficacy among different individuals.In recent years,with the gradual deepening of genetic polymorphism related research,the relationship between IL-17 gene polymorphism and genetic susceptibility to psoriasis has been widely studied.Currently,genome-wide association studies have been conducted globally on the IL-17 gene,which is closely related to the risk of psoriasis in multiple populations,and gene level analysis has been conducted on the response of different individuals to approved biological agents.In the future,in-depth research on the relationship between IL-17 gene polymorphism and psoriasis has important clinical significance for the treatment of psoriasis.