m^(6)A甲基化修饰在透明细胞肾细胞癌中的研究进展

RNA Research Progress of m^(6)A Methylation Modification in Clear Cell Renal Cell Carcinoma

N^(6)-甲基腺嘌呤(m^(6)A)甲基化是真核生物体内最常见的RNA修饰之一,广泛见于信使RNA和非编码RNA中,介导RNA的加工、出核、翻译和降解等。透明细胞肾细胞癌(ccRCC)是最常见的泌尿系统恶性肿瘤之一,具有易侵袭、易转移和预后效果差的特点,严重威胁患者生命。截至目前,国内外对于m^(6)A甲基化修饰及其相关调节因子参与ccRCC发生发展的研究,主要集中于细胞恶性增殖、侵袭、迁移和耐药等方面。m^(6)A调节因子在ccRCC组织标本中异常表达,其有望作为潜在的分子标志物,实现今后对ccRCC的精准诊断、分型及治疗。

Methylation of N^(6)-methyladenosine(m^(6)A)is one of the most common RNA modifications in eukaryotic organisms,widely found in messenger RNA and non-coding RNA,mediating RNA processing,nucleation,translation and degradation.Clear cell renal cell carcinoma(ccRCC)is one of the most common malignant tumors of the urinary system,characterized by easy invasion,metastasis,and poor prognosis,which seriously threatens the patient life.Up to now,domestic and international research on m^(6)A methylation modification and its related regulatory factors participating in the occurrence and development of ccRCC has mainly focused on aspects such as cell malignant proliferation,invasion,migration,and drug resistance.The abnormal expression of m^(6)A regulatory factor in ccRCC tissue samples is expected to serve as a potential molecular marker for precise diagnosis,typing,and treatment of ccRCC in the future.