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养血清脑丸联合氯吡格雷治疗高龄短暂性脑缺血发作临床研究

Clinical Study on Yangxue Qingnao Pills Combined with Clopidogrel for Transient Ischemic Attack in the Senile
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摘要 目的:观察养血清脑丸联合氯吡格雷治疗高龄短暂性脑缺血发作(TIA)的临床疗效。方法:选取高龄TIA患者100例,采用随机数字表法分为对照组及观察组各50例。对照组给予氯吡格雷抗凝治疗,观察组在对照组基础上联合养血清脑丸治疗。比较2组临床疗效、中医证候评分、血液流变学指标(全血黏度、血浆黏度以及纤维蛋白原)水平、不良反应发生率。结果:观察组总有效率为98.00%,对照组为82.00%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组眩晕、头痛、失眠、视物模糊、急躁易怒等中医证候评分比较,差异均无统计学意义(P>0.05)。治疗后,2组上述各项证候评分均较治疗前下降(P<0.05),且观察组各项评分均低于对照组(P<0.05)。治疗前,2组全血黏度、血浆黏度以及纤维蛋白原水平比较,差异均无统计学意义(P>0.05);治疗后,2组上述各项血液流变学指标水平均较治疗前降低(P<0.05),且观察组各项指标均低于对照组(P<0.05)。观察组不良反应发生率为22.00%,对照组为10.00%,2组比较,差异无统计学意义(P>0.05)。结论:养血清脑丸联合氯吡格雷治疗高龄TIA疗效显著,可有效缓解临床症状,改善血液流变学状态,且安全性良好。 Objective:To observe the clinical effect of Yangxue Qingnao Pills combined with Clopidogrel for transient ischemic attack(TIA)in the senile.Methods:A total of 100 senile TIA patients were selected and randomly divided into the control group and the observation group according to the random number table method,with 50 cases in each group.The control group was treated with Clopidogrel anticoagulation therapy,and the observation group was treated with Yangxue Qingnao Pills on the basis of the treatment of the control group.The levels of hemorheological indicators(whole blood viscosity,plasma viscosity,and fibrinogen),as well as clinical effects,traditional Chinese medicine(TCM)syndrome scores,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 98.00%in the observation group,and 82.00%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the scores of TCM syndromes such as dizziness,headache,insomnia,blurred vision,and irritability between the two groups(P>0.05).After treatment,the scores of the above syndromes in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in whole blood viscosity,plasma viscosity,and fibrinogen levels between the two groups(P>0.05).After treatment,the above hemorheological indicators in the two groups were decreased when compared with those before treatment(P<0.05),and the indicators in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 22.00%in the observation group,and 10.00%in the control group,there being no significance in the difference between the two groups(P>0.05).Conclusion:The combination of Yangxue Qingnao Pills and Clopidogrel has a significant curative effect on senile TIA,which can effectively alleviate clinical symptoms,improve hemorheological status,and has good safety.
作者 沈扬灵 季丽 吴玉 SHEN Yangling;JI Li;WU Yu(Department of Neurology,Lishui People's Hospital,Lishui Zhejiang 323000,China)
出处 《新中医》 CAS 2023年第22期49-52,共4页 New Chinese Medicine
关键词 短暂性脑缺血发作 高龄 养血清脑丸 氯吡格雷 血液流变学 Transient ischemic attack Senility Yangxue Qingnao Pills Clopidogrel Hemorrheology
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