固本解毒汤联合重组人干扰素α-2a栓对宫颈高危型人乳头瘤病毒感染及阴道微生态的影响

Effect of Guben Jiedu Decoction Combined with Recombinant Human Interferonα-2a Vaginal Suppository on Cervical High-Risk Human Papillomavirus Infection and Vaginal Microenvironment

目的:观察固本解毒汤联合重组人干扰素α-2a栓治疗脾虚湿热型宫颈高危型人乳头瘤病毒(HPV)感染的效果及对患者阴道微生态的影响。方法:纳入90例脾虚湿热型宫颈高危型HPV感染患者,以随机数字表法分为2组各45例,对照组以重组人干扰素α-2a栓治疗,治疗组在对照组基础上给予固本解毒汤治疗。2组均于每个月经期结束后3 d用药,治疗18 d后停药,以此为1个疗程,连续治疗3个疗程。治疗前、治疗3个疗程后评定中医证候积分,统计HPV转阴率、低度鳞状上皮内病变(LSIL)逆转率、阴道微生态恢复情况,比较2组临床疗效。结果:治疗后,治疗组总有效率、HPV转阴率、LSIL逆转率及阴道微生态恢复正常率均高于对照组(P<0.05)。2组中医证候积分均较治疗前降低(P<0.05),治疗组中医证候积分低于对照组(P<0.05)。治疗组阴道pH值低于对照组(P<0.05)。结论:采用固本解毒汤联合重组人干扰素α-2a栓治疗脾虚湿热型宫颈高危型HPV感染患者疗效显著,有利于减轻症状、体征,促进HPV转阴和LSIL逆转,并改善阴道微生态环境。

Objective:To observe the effect of Guben Jiedu Decoction combined with Recombinant Human Interferonα-2a Vaginal Suppository on cervical high-risk human papillomavirus(HPV)infection of spleen deficiency with damp-heat type and vaginal microenvironment of the patients.Methods:A total of 90 cases of patients with cervical high-risk HPV infection of spleen deficiency with damp-heat type were included and divided into two groups according to the random number table method,with 45 cases in each group.The control group was treated with Recombinant Human Interferonα-2a Vaginal Suppository,and the treatment group was treated with Guben Jiedu Decoction based on the treatment of the control group.Both groups were given 3 consecutive courses of treatment;during each treatment course,the two groups received medication 3 days after the end of menstrual period,and stopped taking medication after 18 days of treatment.Before treatment and after 3 courses of treatment,the traditional Chinese medicine(TCM)syndrome scores were evaluated,and the negative conversion rates of HPV,the reversal rates of low-grade squamous intraepithelial lesions(LSIL),and the recovery of vaginal microenvironment were calculated.The clinical effects in the two groups were compared.Results:After treatment,the total effective rate,the negative conversion rate of HPV,the reversal rate of LSIL,and the rate of vaginal microenvironment back to normal in the treatment group were higher than those in the control group(P<0.05).TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score in the treatment group was lower than that in the control group(P<0.05).The vaginal pH value in the treatment group was lower than that in the control group(P<0.05).Conclusion:Guben Jiedu Decoction combined with Recombinant Human Interferonα-2a Vaginal Suppository has a significant curative effect in the treatment of patients with cervical high-risk HPV infection of spleen deficiency with damp-heat type and can help relieve symptoms and signs,promote HPV negative and LSIL reversal,and improve the vaginal microenvironment.