心力衰竭超声指数联合血清CA125、BNP对老年舒张性心力衰竭MACE的预测价值

Predictive Value of Cardiac Failure Ultrasound Index Combined with Serum CA125 and BNP for MACE in Senile Diastolic Heart Failure

目的探讨心力衰竭超声指数(HFEI)联合血清糖类抗原-125(CA125)、B型钠尿肽(BNP)对老年舒张性心力衰竭(DHF)患者不良心血管事件(MACE)的预测价值。方法选取郑州颐和医院2021年3月至2022年3月收治的78例老年DHF患者,根据患者在随访期间是否出现MACE分为未发生MACE患者(对照组43例)和发生MACE患者(观察组35例)。比较对照组与观察组临床资料及HFEI[左室舒张末期内径(LVEDd)、左室射血分数(LVEF)、张早期充盈峰值速度/舒张末期充盈峰值速度(E/A)]、血清CA125、BNP水平;分析老年DHF患者MACE的影响因素;分析HFEI、血清CA125、BNP预测MACE的效能,并绘制受试者工作曲线(ROC)曲线。结果观察组LVEDd、HFEI、CA125、BNP高于对照组,差异有统计学意义(P<0.05),LVEF、E/A低于对照组,差异有统计学意义(P<0.05);HFEI、CA125、BNP均是老年DHF患者MACE的独立危险因素,差异有统计学意义(P<0.05);HFEI、CA125、BNP联合检测预测MACE的曲线下面积(AUC)值均高于单项检测,差异有统计学意义(P<0.05)。结论心力衰竭超声指数联合血清CA125、BNP对老年DHF患者MACE的预测价值较高。

Objective To investigate the heart failure predictive value of ultrasound index(HFEI)combined with serum carbohydrate antigen 125(CA125)and B-type natriuretic peptide(BNP)for adverse cardiovascular events(MACE)in elderly patients with diastolic heart failure(DHF).Methods Seventy-eight elderly DHF patients admitted to Zhengzhou Yihe Hospital from March 2021 to March 2022 were selected.According to whether the patients developed MACE during the follow-up period,they were divided into patients without MACE(43 cases in the control group)and patients with MACE(35 cases in the observation group).The clinical data,HFEI[Left ventricular end-diastolic Diameter(LVEDd),left ventricular ejection fraction(LVEF),Peak early diastolic filling velocity/Peak end diastolic filling velocity(E/A)],serum CA125 and BNP levels of the control group and the observation group were compared.The influencing factors of MACE in elderly DHF patients were analyzed.The predictive efficacy of HFEI,serum CA125 and BNP for MACE was analyzed,and ROC curve was drawn.Results LVEDd,HFEI,CA125 and BNP in the observation group were higher than those in the control group(P<0.05),while LVEF and E/A in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).HFEI,CA125 and BNP were independent risk factors for MACE in elderly DHF patients,the difference was statistically significant(P<0.05).The area under the curve(AUC)value of MACE predicted by HFEI,CA125 and BNP combined detection was higher than that by single detection,the difference was statistically significant(P<0.05).Conclusion The value of heart failure ultrasound index combined with serum CA125 and BNP in predicting MACE in elderly DHF patients is higher.