多潘立酮联合奥美拉唑对功能性消化不良患者的疗效观察

Observation of the Therapeutic Effect of Domperidone Combined with Omeprazole on Patients with Functional Dyspepsia

目的探讨功能性消化不良(FD)患者采用多潘立酮联合奥美拉唑治疗的应用效果。方法选取2021年5月至2022年4月杞县人民医院收治的共计104例FD患者,按照随机数字表法分成研究组(n=52)与对照组(n=52),对照组采用奥美拉唑治疗,研究组采用多潘立酮联合奥美拉唑治疗,对两组临床疗效、临床症状评分、胃肠激素水平及不良反应进行比较。结果研究组治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗后两组临床症状(上腹痛、餐后饱腹、上腹部灼烧感)评分降低,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后两组胃动素(MOT)、促胃泌素(GAS)水平升高,生长抑素(SS)水平降低,且研究组MOT、GAS水平更高,SS更低,差异有统计学意义(P<0.05);研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论多潘立酮联合奥美拉唑应用于FD患者治疗中,可提高临床疗效,缓解临床症状,改善胃肠激素水平,减少不良反应发生。

Objective To explore the application effect of domperidone combined with omeprazole in the treatment of patients with functional dyspepsia(FD).Methods A total of 104 FD patients admitted to Qi County People’s Hospital from May 2021 to April 2022 were selected and divided into the research group(n=52)and the control group(n=52)according to the random number table method.The control group was treated with omeprazole,and the research group was treated with domperidone combined with omeprazole.The clinical efficacy,clinical symptom score,gastrointestinal hormone level,and adverse reactions of the two groups were compared.Results The effective rate of treatment in the research group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the clinical symptom scores(upper abdominal pain,postprandial fullness,upper abdominal burning sensation)of the two groups decreased,and the research group was lower than the control group,the difference was statistically significant(P<0.05).After treatment,the levels of motilin(MOT)and gastrin(GAS)in the two groups increased,and the level of somatostatin(SS)decreased.The MOT and GAS levels in the research group were higher,and SS was lower,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the research group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of domperidone combined with omeprazole in the treatment of FD patients can improve the clinical efficacy,alleviate clinical symptoms,improve gastrointestinal hormone levels,and reduce the occurrence of adverse reactions.