腺泡细胞钙离子超载与急性胰腺炎关系的研究进展

Research progress on the relationship between calcium overload in acinar cells and acute pancreatitis

急性胰腺炎(AP)是消化科的常见的疾病类型之一,大多数患者病情轻微,但约25%的患者会发展为重症胰腺炎,其中重症胰腺炎的致死率则高达30%~50%。国内诸多对AP病因病机的基础研究显示,使用雨蛙素法、无胆盐乙硫氨酸食物诱导法、胆胰管逆行牛黄胆酸钠注射法诱导的AP动物模型中腺泡细胞内钙离子浓度均持续增高,进而引起胞内钙离子依赖性的酶原颗粒提前活化、空泡形成最终导致细胞凋亡,以上结论均提示腺泡细胞钙离子超载在AP的发生发展中起到至关重要的作用,而针对AP的治疗目前临床上缺乏高效且具有针对性的靶向药物,故探索维持细胞内钙稳态的机制及腺泡细胞钙超载所引起的病理过程,可为研究AP的直接靶向治疗药物提供新思路。该文就细胞内钙稳态与调控、腺泡细胞钙超载的发生、Ca2+超载在AP发病机制中的作用、腺泡细胞Ca2+超载的临床诊治方法的研究进展作一综述。

Acute pancreatitis(AP)is one of the most common diseases in the department of gastroenterology.Most patients are mild,but about 25%of patients develop severe pancreatitis,and the fatality rate of severe pancreatitis is as high as 30%-50%.Domestic,according to a lot of basic research on the etiology and pathogenesis of AP use hyla element method,induction method,bravery,no bile salts b methionine food pancreatic duct retrograde bezoar AP animal models induced by bile acid sodium injection acini intracellular calcium ion concentration are rising,resulting in intracellular calcium dependent enzyme activation and cavitation in advance of the original particles into ultimately lead to cell apoptosis,the above conclusions are prompted acinar cell calcium overload play a crucial role in the occurence and development of AP,and treatment for the AP is lack of efficient and clinical targeted drugs targeted,so the exploring to maintain the mechanism of intracellular calcium homeostasis and acinar cells of the pathological process of calcium overload caused by,for the research of the AP directly targeted drugs provide a new way of thinking.In this review,intracellular calcium homeostasis and regulation,calcium overload in acinar cells,the role of Ca2 overload in the pathogenesis of AP,and the clinical diagnosis and treatment of Ca**overload in acinar cells are reviewed.