加服五苓散加减治疗脾肾阳虚型痛风性关节炎临床观察

Adding modified Wuling powder in the treatment of gouty arthritis with yang deficiency of spleen and kidney

目的:观察加服五苓散加减治疗脾肾阳虚型痛风性关节炎的临床疗效。方法:选取90例脾肾阳虚型痛风性关节炎患者,根据随机数字表法分为治疗组和对照组各45例。两组患者均予艾瑞昔布胶囊口服,对照组加服非布司他片,观察组加服五苓散加减方,两组均连续治疗14 d。观察并比较两组治疗前、治疗结束时、治疗后14 d、治疗后1个月的疼痛视觉模拟评分量表(VAS)评分、关节肿胀程度、关节活动情况及实验室指标(血尿酸、血沉、C反应蛋白)水平。结果:治疗结束、治疗后14 d、治疗后1个月治疗组的疼痛VAS评分、关节肿胀评分、关节活动评分及实验室指标(血尿酸、血沉、C反应蛋白)水平均较治疗前降低,且治疗后14 d、治疗后1个月治疗组上述评分及指标低于对照组(P<0.05)。结论:五苓散加减治疗脾肾阳虚型痛风性关节炎可缓解患者症状,改善关节活动情况,降低实验室指标(血尿酸、血沉及C反应蛋白)水平,值得临床推广应用。

Objective:To observe the clinical efficacy of adding Wuling powder in the treatment of gouty arthritis with yang deficiency of spleen and kidney.Methods:90 patients with gouty arthritis of yang deficiency of spleen and kidney were selected and divided into treatment group and control group according to the random number table method,with 45 cases in each group.Both groups were given oral administration of imrecoxib capsules,the control group was additionally given febuxostat tablets,and the observation group was additionally given modified Wuling powder.Both groups were treated continuously for 14 days.The pain visual analogue scale(VAS)score,joint swelling degree,joint activity and laboratory indexes(blood uric acid,erythrocyte sedimentation rate,C-reactive protein)were observed and compared between the two groups before treatment,at the end of treatment,14 days after treatment and 1 month after treatment.Results:At the end of treatment,14 days after treatment and 1 month after treatment,the pain VAS score,joint swelling score,joint activity score and laboratory indexes(blood uric acid,erythrocyte sedimentation rate and Creactive protein)in the treatment group were lower than those before treatment,and those in the treatment group were lower than those in the control group at 14 days after treatment and 1 month after treatment(P<0.05).Conclusion:Adding modified Wuling powder in the treatment of gouty arthritis of yang deficiency of spleen and kidney can relieve symptom,improve joint activity,reduce the level of laboratory indexes(blood uric acid,erythrocyte sedimentation rate,C-reactive protein),which is worthy of applying in the clinical practice.