单操作孔电视胸腔镜肺癌根治术治疗非小细胞肺癌患者的疗效观察

Observation on the efficacy of single-port video-assisted thoracoscopic lung cancer radical surgery in the treatment of patients with non-small cell lung cancer

目的观察单操作孔电视胸腔镜(VATS)肺癌根治术对非小细胞肺癌(NSCLC)血管内皮生长因子受体2(VEGFR2)、胸苷激酶1(TK1)水平的影响。方法我院收治的245例NSCLC患者,按手术方式分为对照组(三孔胸腔镜肺癌根治术,n=115)和观察组(单操作孔VATS肺癌根治术,n=130),比较两组围术期指标、视觉模拟(VAS)评分、肺功能、炎性因子、肿瘤标志物、VEGFR2、TK1水平及并发症。结果观察组术中出血量较对照组少(P<0.05);术后,观察组VAS评分、炎性因子、肿瘤标志物和VEGFR2、TK1水平低于对照组,肺功能高于对照组(P<0.05)。结论单操作孔VATS肺癌根治术治疗NSCLC出血量少、疼痛轻,可改善肺功能,降低炎性因子、肿瘤标志物和VEGFR2、TK1水平,且不增加术后并发症,值得临床推广。

Objective To observe the effect of single-hole video-assisted thoracoscopic lung cancer radical surgery(VATS)for non-small cell lung cancer(NSCLC)on the level s of serum vascular endothelial growth factor receptor 2(VEGFR2)and thymidine kinase 1(TK1).Methods A total of 245 patients with NSCLC in our hospital were divided into a control group(n=115)and an observation group(n=130)according to treatment methods.The control group was treated with three-port thoracoscopic radical resection of lung cancer.The observation group was treated with single-port VATS radical resection of lung cancer.Perioperative indicators,Visual analogue(VAS)scores,pulmonary function,inflammatory factors,tumor markers,serum VEGFR2 and TK1 levels,and the incidence of complications were compared between the groups.Results The blood loss in the observation group was less than that in the control group(P<0.05).After surgery,VAS scores,inflammatory factors,tumor markers,VEGFR2 and TK1 levels in the observation group were lower than those in the control group.The lung function in the observation group was higher than that in the control group(P<0.05).Conclusions Single-hole VATS resection of lung cancer has the advantages of less blood loss and milder pain during operation.It can improve the patients'pulmonary function and lower the levels of inflammatory factors,tumor markers,VEGFR2 and TKI without increasing postoperative complications.It is worthy of clinical promotion.