神经介入结合神经外科治疗动脉瘤性蛛网膜下腔出血的效果分析

Effect analysis of neurointervention combined with neurosurgery in the treatment of aneurysmal subarachnoid hemorrhage

目的分析神经介入结合神经外科治疗动脉瘤性蛛网膜下腔出血(aSAH)的临床效果。方法选择在本院就诊的72例动脉瘤性蛛网膜下腔出血患者资料(2019年1月~2022年10月),根据治疗方案的不同分成对照组(36例,神经介入治疗)和治疗组(36例,神经介入结合神经外科治疗)。对比两组神经功能指标、炎症反应指标、并发症发生情况、病情控制效果及神经功能恢复时间和住院治疗时间。结果治疗后,治疗组神经肽Y(119.78±18.43)μg/L、同型半胱氨酸(17.08±5.24)μmol/L、神经元特异性烯醇化酶(32.35±4.36)μg/L、中枢神经特异性蛋白100β(7.10±0.55)μg/L较对照组的(146.80±21.36)μg/L、(25.19±6.30)μmol/L、(47.01±6.56)μg/L、(10.61±1.76)μg/L更低(P<0.05)。治疗后,治疗组白介素-6(IL-6)(86.57±24.36)ng/L、白细胞计数(WBC)(4.13±0.75)×10^(9)/L、C反应蛋白(CRP)(8.43±1.68)mg/L、肿瘤坏死因子-α(TNF-α)(41.93±4.36)ng/L较对照组的(143.06±25.91)ng/L、(11.75±1.62)×10^(9)/L、(12.16±2.05)mg/L、(195.73±15.27)ng/L更低(P<0.05)。治疗组并发症发生率为2.78%较对照组的19.44%更低(P<0.05)。治疗组治疗总有效率为91.67%较对照组的69.44%更高(P<0.05)。治疗组神经功能恢复时间(6.62±1.44)d和住院治疗时间(8.17±1.18)d较对照组的(9.38±1.51)、(12.92±2.50)d更短(P<0.05)。结论动脉瘤性蛛网膜下腔出血患者接受神经介入结合神经外科治疗,能够帮助改善其神经功能,控制炎症反应,减少相关并发症,缩短恢复时间和治疗时间。

Objective To analyze the clinical effect of neurointervention combined with neurosurgery in the treatment of aneurysmal subarachnoid hemorrhage(aSAH).Methods 72 patients with aneurysmal subarachnoid hemorrhage treated in our hospital(January 2019 to October 2022)were selected as examples,and divided into control group(36 cases,neurointerventional therapy)and treatment group(36 cases,neurointerventional therapy combined with neurosurgery)according to different treatment plans.Both groups were compared in terms of neurological function index,inflammatory response markers,complication occurrence,disease control effect,neurological recovery time and hospitalization time.Results After treatment,the treatment group had neuropeptide Y of(119.78±18.43)μg/L,homocysteine of(17.08±5.24)μmol/L,neuron-specific enolase of(32.35±4.36)μg/L,and nervous system specific protein 100βof(7.10±0.55)μg/L,which were lower than those of(146.80±21.36)μg/L,(25.19±6.30)μmol/L,(47.01±6.56)μg/L,and(10.61±1.76)μg/L in the control group(P<0.05).After treatment,the treatment group had interleukin-6(IL-6)of(86.57±24.36)ng/L,white blood cell count(WBC)of(4.13±0.75)×10^(9)/L,C-reactive protein(CRP)of(8.43±1.68)mg/L,and tumor necrosis factor-α(TNF-α)of(41.93±4.36)ng/L,which were lower than those of(143.06±25.91)ng/L,(11.75±1.62)×10^(9)/L,(12.16±2.05)mg/L,and(195.73±15.27)ng/L in the control group(P<0.05).The incidence of complications of 2.78%in the treatment group was lower than that of 19.44%in the control group,and the difference was statistically significant(P<0.05).The total effective rate in the treatment group was 91.67%,which was higher than that of 69.44%in the control group(P<0.05).The neurological recovery time of(6.62±1.44)d and hospitalization time of(8.17±1.18)d in the treatment group were shorter than those of(9.38±1.51)and(12.92±2.50)d in the control group(P<0.05).Conclusion Neurointervention combined with neurosurgery in the treatment of patients with aneurysmal subarachnoid hemorrhage can help improve their neurological function,control inflammation,reduce related complications,shorten recovery time and treatment time.