左氧氟沙星联合盐酸氨溴索与阿奇霉素治疗慢性支气管炎对患者体液免疫水平的影响

Effect of levofloxacin combined with ambroxol hydrochloride and azithromycin on humoral immunity level in patients with chronic bronchitis

目的探究左氧氟沙星联合盐酸氨溴索、阿奇霉素治疗慢性支气管炎(CB)对患者体液免疫水平的影响。方法选取2018年1月至2020年1月德兴市中医院收治的80例CB患者作为研究对象,采用随机数字表法分为对照组与实验组,各40例。对照组采用盐酸氨溴索联合阿奇霉素治疗,实验组在对照组基础上联合左氧氟沙星治疗,比较两组临床疗效、体液免疫指标(IgA、IgM和IgG)、炎症因子[肿瘤坏死因子-α(TNF-α)与和白细胞介素-6(IL-6)]水平及不良反应发生情况。结果实验组治疗总有效率为92.5%,高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗前,两组IgA、IgM、IgG水平比较差异无统计学意义;治疗后,两组IgA、IgG水平均高于治疗前,且实验组高于对照组,差异有统计学意义(P<0.05);两组IgM水平治疗前后及组间比较差异无统计学意义。治疗前,两组TNF-α、IL-6水平比较差异无统计学意义;治疗后,两组TNF-α、IL-6水平均低于治疗前,且实验组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论左氧氟沙星联合盐酸氨溴索、阿奇霉素治疗CB疗效确切,可一定程度改善患者体液免疫水平,减少炎症反应,值得临床推广应用。

Objective To explore the effects of levofloxacin combined with ambroxol hydrochloride and azithromycin on humoral immunity level in patients with chronic bronchitis(CB).Methods A total of 80 CB patients admitted to Dexing Hospital of Traditional Chinese Medicine from January 2018 to January 2020 were selected as research subjects,and they were divided into the control group and the experimental group,with 40 cases in each group by random number table method.The control group was treated with ambroxol hydrochloride combined with azithromycin,and the experimental group was treated with levofloxacin on the basis of the control group,the clinical efficacy,humoral immune indexes(IgA,IgM and IgG),the levels of inflammatory factors(tumor necrosis factor-α[TNF-α]and interleukin-6[IL-6])and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the experimental group was 92.5%,which was higher than 75.00%in the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in IgA,IgM and IgG levels between the two groups;after treatment,the levels of IgA and IgG of the two groups were higher than before treatment,and the experimental group was higher than the control group,the differences were statistically significant(P<0.05);there was no significant difference in IgM level between the two groups before and after treatment.Before treatment,there were no significant differences in TNF-αand IL-6 levels between the two groups;after treatment,the levels of TNF-αand IL-6 of the two groups were lower than before treatment,and the experimental group was lower than the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Levofloxacin combined with ambroxol hydrochloride and azithromycin are effective in the treatment of CB,which can improve humoral immunity and reduce inflammation in patients to a certain extent,and is worthy of clinical promotion and application.