摘要
Primary liver cancer is a severe and complex disease,leading to 800000 global deaths annually.Emerging evidence suggests that inflammation is one of the critical factors in the development of hepatocellular carcinoma(HCC).Patients with viral hepatitis,alcoholic hepatitis,and steatohepatitis symptoms are at higher risk of developing HCC.However,not all inflammatory factors have a pathogenic function in HCC development.The current study describes the process and mechanism of hepatitis development and its progression to HCC,particularly focusing on viral hepatitis,alcoholic hepatitis,and steatohepatitis.Furthermore,the roles of some essential inflammatory cytokines in HCC progression are described in addition to a summary of future research directions.
基金
Supported by the National Natural Science Foundation of China,No.82260567
Science and Technology Fund of Guizhou Provincial Health Commission,No.gzwkj2022-082
Excellent Young Talents Plan of Guizhou Medical University,No.2023(112)
Taizhou Social Development Science and Technology Plan Project,No.23ywb146
and Start-up Fund of Guizhou Medical University,No.J2021032.
