摘要
肾容易受到体内外各种物理、化学和生物因素的影响,致使肾功能损害,造成急慢性肾疾病。预防和治疗各种因素引起的肾功能损害是泌尿系统研究的重要内容。斑马鱼幼鱼通体透明、产卵量大、易于基因编辑,在肾的形态、生理、功能等方面以及对化合物的反应也与人类具有很高的相似性,是理想的动物模型。本文将对斑马鱼肾损伤造模方法及评价指标进行综述。
Kidneys filter bloodand regulate fluid and electrolyte balances.However,the kidney is susceptible to toxicity of various compounds,Resulting in renal damage.Hence,prevention and treatment of renal injury is a hot research topic.Zebrafish is an ideal animal model,because it is closely related to humans in terms of morphology,physiology,and kidney functions and its response to compounds.In this article,we review the method and evaluation indexes of zebrafish kidney injury modeling.
作者
兰爱琳
黄春华
夏铭
李茂娟
汪思齐
楼迪栋
LAN Ailin;HUANG Chunhua;XIA Ming;LI Maojuan;WANG Siqi;LOU Didong(Guizhou Provincial Key Laboratory of Forensic Medicine Toxicology,Judicial Appraisal Center,Guizhou University of Traditional Chinese Medicine,Guiyang 550000,China)
出处
《中国比较医学杂志》
CAS
北大核心
2023年第12期123-126,共4页
Chinese Journal of Comparative Medicine
基金
贵州省法医中药毒理学特色重点实验室(黔教合KY字[2021]004)。
关键词
斑马鱼
肾损伤
动物模型
zebrafish
kidney injury
animal models Conflicts of Interest:The authors declare no conflict of interest.