粪钙卫蛋白、血浆D-二聚体在不同类型过敏性紫癜患儿中的表达水平及其诊断价值

Expression levels and diagnostic value of fecal calprotectin and plasma D-dimer in children with different types of henoch-schonlein purpura

目的:探讨粪钙卫蛋白、血浆D-二聚体在不同类型过敏性紫癜(HSP)患儿中的表达水平及其诊断价值。方法:选取2019年10月至2022年6月我科收治的66例首次发病的HSP儿童为病例组,分为腹型组(40例)与非腹型组(26例),非腹型组又细分为肾脏受累组(10例)和肾脏未受累组(16例)。选取同期我院50例健康体检儿童为对照组,比较各组粪钙卫蛋白与血浆D-二聚体水平,采用ROC曲线分析二者对HSP的诊断价值。结果:腹型组的粪钙卫蛋白、血浆D-二聚体水平高于非腹型组,非腹型组高于对照组(P<0.05)。肾脏受累组的血浆D-二聚体水平高于肾脏未受累组(P<0.05)。ROC曲线分析显示,粪钙卫蛋白、血浆D-二聚体诊断HSP的曲线下面积为0.890、0.919。粪钙卫蛋白、血浆D-二聚体水平与HSP患儿腹部受累程度呈正相关(r=0.676、0.630,P<0.05)。结论:粪钙卫蛋白、血浆D-二聚体可作为诊断儿童HSP的重要生物学标志,其表达水平与HSP腹部受累程度呈正相关。

Objective:To explore the expression levels and diagnostic value of fecal calprotectin and plasma D-dimer in children with different types of henoch-schonlein purpura(HSP).Methods:66 children with first-time onset of HSP admitted to our department from October 2019 to June 2022 were selected as the case group which was divided into abdominal type group(40 cases)and non-abdominal type group(26 cases).The non-abdominal type group was further divided into renal involvement group(10 cases)and renal non-involvement group(16 cases).50 healthy children who underwent physical examinations in our hospital during the same period were selected as control group.The levels of fecal calprotectin and plasma D-dimer in each group were compared,and their diagnostic value for HSP was analyzed using ROC curves.Results:The levels of fecal calprotectin and plasma D-dimer in the abdominal type group were higher than those in the non-abdominal type group,and they were higher in the non-abdominal type group than those in the control group(P<0.05).The plasma D-dimer level in the renal involvement group was higher than that in the renal non-involvement group(P<0.05).ROC curve analysis showed that the area under the curve of fecal calprotectin and plasma D-dimer for diagnosing HSP was 0.890 and 0.919,respectively.Fecal calprotectin and plasma D-dimer levels were positively correlated with the degree of abdominal involvement in children with HSP(r=0.676,0.630,P<0.05).Conclusion:Fecal calprotectin and plasma D-dimer can serve as important biological markers for diagnosing HSP in children,and their expression levels are positively correlated with the degree abdominal involvement of HSP.