摘要
目的:探讨粪钙卫蛋白、血浆D-二聚体在不同类型过敏性紫癜(HSP)患儿中的表达水平及其诊断价值。方法:选取2019年10月至2022年6月我科收治的66例首次发病的HSP儿童为病例组,分为腹型组(40例)与非腹型组(26例),非腹型组又细分为肾脏受累组(10例)和肾脏未受累组(16例)。选取同期我院50例健康体检儿童为对照组,比较各组粪钙卫蛋白与血浆D-二聚体水平,采用ROC曲线分析二者对HSP的诊断价值。结果:腹型组的粪钙卫蛋白、血浆D-二聚体水平高于非腹型组,非腹型组高于对照组(P<0.05)。肾脏受累组的血浆D-二聚体水平高于肾脏未受累组(P<0.05)。ROC曲线分析显示,粪钙卫蛋白、血浆D-二聚体诊断HSP的曲线下面积为0.890、0.919。粪钙卫蛋白、血浆D-二聚体水平与HSP患儿腹部受累程度呈正相关(r=0.676、0.630,P<0.05)。结论:粪钙卫蛋白、血浆D-二聚体可作为诊断儿童HSP的重要生物学标志,其表达水平与HSP腹部受累程度呈正相关。
Objective:To explore the expression levels and diagnostic value of fecal calprotectin and plasma D-dimer in children with different types of henoch-schonlein purpura(HSP).Methods:66 children with first-time onset of HSP admitted to our department from October 2019 to June 2022 were selected as the case group which was divided into abdominal type group(40 cases)and non-abdominal type group(26 cases).The non-abdominal type group was further divided into renal involvement group(10 cases)and renal non-involvement group(16 cases).50 healthy children who underwent physical examinations in our hospital during the same period were selected as control group.The levels of fecal calprotectin and plasma D-dimer in each group were compared,and their diagnostic value for HSP was analyzed using ROC curves.Results:The levels of fecal calprotectin and plasma D-dimer in the abdominal type group were higher than those in the non-abdominal type group,and they were higher in the non-abdominal type group than those in the control group(P<0.05).The plasma D-dimer level in the renal involvement group was higher than that in the renal non-involvement group(P<0.05).ROC curve analysis showed that the area under the curve of fecal calprotectin and plasma D-dimer for diagnosing HSP was 0.890 and 0.919,respectively.Fecal calprotectin and plasma D-dimer levels were positively correlated with the degree of abdominal involvement in children with HSP(r=0.676,0.630,P<0.05).Conclusion:Fecal calprotectin and plasma D-dimer can serve as important biological markers for diagnosing HSP in children,and their expression levels are positively correlated with the degree abdominal involvement of HSP.
作者
樊省廉
杨晓晴
何勤
Fan Shenglian;Yang Xiaoqing;He Qin(Department of Pediatrics,Guilin People's Hospital,Guilin,Guangxi 541002,China)
出处
《现代临床医学》
2024年第1期5-8,共4页
Journal of Modern Clinical Medicine
基金
桂林市科学技术局科研课题(20190218-7-11)。