肺炎衣原体、支原体感染与动脉粥样硬化的关联分析

Association between chlamydia pneumoniae,mycoplasma infection and atherosclerosis

目的了解成年群体肺炎衣原体、支原体感染情况及其与动脉粥样硬化发生的关联性,为该类疾病预防提供理论指导。方法采用病例对照研究,收集2019年1月至2021年12月在巴中市中心医院就医并确诊为动脉粥样硬化患者362例为病例组,选择同期入院体检并无任何心血管疾病370例为对照组,采集两组研究对象的全血样本,PCR法检测患者的肺炎衣原体、支原体感染情况。结果病例组肺炎衣原体感染率为35.49%,支原体感染率为40.37%,混合感染率为11.37%;对照组肺炎衣原体感染率为12.04%,支原体感染率为15.83%,混合感染率为3.14%,两组差异具有统计学意义(X^(2)=10.926,P=0.023)。支原体、衣原体以及混合感染对于动脉粥样硬化患者影响具有性别差异,主要表现为男性感染率更高。此外,支原体、衣原体以及混合感染对于动脉粥样硬化患者影响具有年龄差异,主要集中于55~70岁年龄段(P<0.05)。多因素logistic回归结果显示,全人群肺炎衣原体感染为动脉粥样硬化的风险因素(OR=1.303,95%CI:1.043~1.677),男性群体中肺炎衣原体(OR=1.472,95%CI:1.037~1.556)、支原体(OR=2.003,95%CI:1.637~3.842)以及混合感染(OR=1.937,95%CI:1.380~2.184)均为动脉粥样硬化的风险因素,而女性群体中混合感染(OR=1.699,95%CI:1.263~1.765)为动脉粥样硬化的风险因素。结论肺炎衣原体、支原体感染为动脉粥样硬化的风险因素,且其对男性群体的影响更大,需给予更多关注。

Objective To investigate the infection of Chlamydia pneumoniae and mycoplasma pneumoniae in adults and their association with atherosclerosis,and to provide theoretical guidance for the prevention of such diseases.Methods A case-control study was used to collect 362 patients who were diagnosed with atherosclerosis from January 2019 to December 2021 in Department of Sichuan Bazhong Central Hospital,and 370 cases who were admitted to the hospital during the same period of physical examination without any cardiovascular disease were selected as the control group,and whole blood samples of the two groups of study subjects were collected,and the infection of Chlamydia pneumoniae and mycoplasma pneumoniae was detected by PCR.Results The infection rate of Chlamydia pneumoniae was 35.49%,the infection rate of mycoplasma was 40.37%,and the co-infection rate was 11.37%;The infection rate of Chlamydia pneumoniae in the control group was 12.04%,the infection rate of mycoplasma was 15.83%,and the coinfection rate was 3.14%,and the difference between the two groups was statistically significant(X^(2)=10.926,P=0.023).The effects of mycoplasma,chlamydia,and co-infection on atherosclerotic patients have sex differences,mainly manifested as higher infection rates in men;In addition,the effects of mycoplasma,chlamydia,and co-infection on atherosclerosis patients varied by age,mainly in the 55-70 years age group(P<0.05).Multivariate logistic regression results showed that Chlamydia pneumoniae infection was a risk factor for atherosclerosis(OR=1.303,95%CI:1.043-1.677)in the whole population,and chlamydia pneumoniae(OR=1.472,95%CI:1.037-1.556),mycoplasma(OR=2.003,95%CI:1.637-3.842)and co-infection in men(OR=1.937,95%CI:1.380-2.184)were risk factors for atherosclerosis,while co-infection in women(OR=1.699,95%CI:1.263-1.765)was a risk factor for atherosclerosis.Conclusion Chlamydia pneumoniae and mycoplasma infection are risk factors for atherosclerosis,and their impact on male groups is greater,and more attention needs to be paid to them.