基于促分裂素原活化蛋白激酶通路影响骨代谢相关中药的研究进展

Research concerning traditional Chinese medicine into correlation between mitogen-activated protein kinases and osteoporosis

骨质疏松症(OP)是由于骨吸收大于骨形成,导致骨量减少、骨质结构变差的一种全身骨代谢性疾病,其并发症导致的致残率、致死率已成为全球公共难题。促分裂素原活化蛋白激酶(MAPK)是调节和维持细胞能量平衡的重要分子,与骨稳态的保持有着密切的联系。从临床实践来看,中医药防治OP具有明显的优势,然而关于祖国传统医学基于该信号通路治疗OP的调节机制仍然缺乏相对全面且系统的归纳总结。因此,基于MAPK信号通路在骨代谢的调节机制,从单味中药及中药复方的角度综述防治OP的作用机制,以期为今后OP相关基础及临床研究提供理论依据。

Osteoporosis(OP)is a systemic bone metabolic disease when bone resorption becomes greater than bone formation,resulting in bone mass loss and poor bone structure.The disability or fatality caused by its complications has become a global public problem.As mitogen-activated protein kinases(MAPK)are important molecules that maintain and regulate cellular energy balance,they are closely related to bone metabolism.In clinical practice,traditional Chinese medicine has demonstrated obvious advantages in prevention and treatment of OP.However,there has not been enough comprehensive or systematic summary of the researches into the regulatory mechanisms of this signaling pathway in the treatment of OP by traditional Chinese medicine.Therefore,this paper expounds on the effects of single traditional Chinese herb and compound traditional Chinese herbs on the regulatory mechanisms of MAPK signaling pathway in bone metabolism so that a theoretical basis can be provided for future basic and clinical researches in the prevention and treatment of OP.