拉曼光谱区分鉴别麻黄碱、伪麻黄碱及氯麻黄碱

Raman Spectroscopy Method to Distinguish Ephedrine,Pseudoephedrine and Chloroephedrine

采用1064 nm激发波长的便携式拉曼及785 nm激发波长的台式拉曼对麻黄碱(EPH)、伪麻黄碱(PSE)及氯麻黄碱(Cl-EPH)进行原位光谱采集,结果1064及785 nm激发波长下的拉曼光谱结果特征差异一致,可通过833,1176 cm^(-1)及551,851,1207 cm^(-1)等特征散射峰位置来重点区分EPH和PSE,通过370,717 cm^(-1)等显著性差异特征峰位置区分鉴别Cl-EPH,从而根据特征散射峰位置及相对强度差异对EPH、PSE及Cl-EPH进行定性区分鉴别。基于拉曼散射峰位置及相对强度等特征差异的拉曼光谱法,对EPH、PSE及Cl-EPH进行区分鉴别具有无损、快速等优势,可实现对结构类似物质的区分鉴别,为禁毒执法人员鉴别EPH、PSE及Cl-EPH提供一种快速、无损的定性方法及参考依据,提高执法人员对易制毒化学品的鉴别效力,为案件侦办及毒品合成路线的判断提供有力的技术支撑。

In situ spectra of ephedrine(EPH),pseudoephedrine(PSE)and chloroephedrine(Cl-EPH)were collected by portable Raman with 1064 nm excitation wavelength and desktop Raman with 785 nm excitation wavelength.The differences in the Raman spectra at 1064 nm and 785 nm excitation wavelengths are consistent,and the EPH and PSE can be distinguished by the positions of the characteristic scattering peaks at 833,1176 cm^(-1)and 551,851,1207 cm^(-1),and the Cl-EPH can be identified by the positions of the characteristic scattering peaks at 370,717 cm^(-1),so that EPH,PSE and Cl-EPH can be distinguished qualitatively according to the positions of the characteristic scattering peaks and the relative intensity differences.Raman spectroscopy,which is based on the difference in the position and relative intensity of Raman scattering peaks,has the advantages of being non-destructive and rapid in the identification of EPH,PSE and Cl-EPH,which enables the identification of structurally similar substances,and provides strong technical support for case investigation and determination of drug synthesis routes.It can provide a rapid and non-destructive qualitative method and reference basis for drug law enforcement officers to identify EPH,PSE and Cl-EPH.