C反应蛋白电化学免疫传感器的研究进展

Research progress of C-reactive protein electrochemical immunosensor

C反应蛋白(CRP)是炎症、心血管、冠心病以及败血症等疾病的临床生物标志物,经常用于评估和监测多种疾病,具有重要的临床意义。电化学免疫传感器具有多功能性、操作简单、成本低以及体积小等特性,已经广泛应用于临床诊断、环境检测、制药工程等领域。基于抗体和适配体2种生物识别元件,分析了这2类电化学免疫传感器的优缺点,概述了其在检测CRP中的研究进展,并展望了CRP电化学免疫传感器的研究方向。

C-reactive protein(CRP)is a clinical biomarker of inflammation,cardiovascular disease,coronary heart disease,sepsis and other diseases.It is often used to evaluate and monitor a variety of diseases,and has important clinical significance.Electrochemical sensors have been widely used in clinical diagnosis,environmental detection,pharmaceutical engineering and other fields because of their versatility,simple operation,low cost and small volume.This paper analyzes the advantages and disadvantages of two kinds of electrochemical immunosensors based on antibody and aptamer recognition respectively,summarizes their research progress in detecting CRP,and prospects the research direction of CRP electrochemical immunosensor in the future.