基于近红外脑功能成像的健康人吞咽热水和冰水过程中脑血流动力学信号的变化

Cerebral hemodynamic signals as healthy people swallow hot and cold water:An infrared spectroscopy study

目的:通过fNIRS探究在吞咽热水和冰水时健康受试者脑血流变化情况,以验证fNIRS对于不同温度液体吞咽任务识别的敏感性,为今后应用fNIRS对吞咽障碍患者进行中枢诊断及干预辅助提供理论依据。方法:纳入符合入组条件的健康受试对象16例,按照随机顺序进行吞咽热水和冰水的任务,并采用fNIRS对任务过程进行记录,配对比较静息状态、吞咽热水和吞咽冰水状态两两之间不同脑区激活程度的差异。结果:相较于静息状态,吞咽热水和冰水时均有19个通道激活,共同激活的皮质包括S1、M1、PMC、SMA、Wernicke区、体感联合皮质、视觉联合皮质和额叶眼动区,DLPFC仅在吞咽热水时激活,中央下区仅在吞咽冰水时激活。SMA和PMC在吞咽热水比吞咽冰水时激活程度更高,差异具有统计性。结论:健康受试者的多个脑区都有激活并参与了吞咽热水和冰水的调控,且吞咽热水比吞咽冰水能够更好的激活健康受试者的PMC和SMA。

Objective To explore the change in cerebral blood flow when healthy subjects swallow hot and ice water,and to verify the sensitivity of functional near-infrared spectroscopy(fNIRS)in identifying liquid tempera-tures while swallowing as a basis for applying it in diagnosis and intervention.Methods Sixteen healthy subjects swallowed hot and ice water in randomized order while the process was recorded using fNIRS.The activation at rest and when swallowing hot and ice water was compared pairwise.Results Compared with the resting state,19 chan-nels were activated during the swallowing of the hot and ice water.The common activated areas were S1,Ml,PMC,SMA,Wernicke's area,the somatosensory association cortex,the visual association cortex and the frontal eye field.However,the dorsal lateral prefrontal cortex was activated only when swallowing hot water,and the subcentral area was activated only when swallowing ice water.The SMA and PMC were significantly more activated when swallowing hot water than ice water.Conclusions Multiple brain regions are activated and participate in regulating swallowing.The PMC and SMA areas can distinguish hot water from ice water swallowing.