sticky bone混合浓缩生长因子应用于水平骨增量患者的临床效果研究

The clinical effect of"sticky bone"mixed with concentrated growth factor on patients with horizontal bone augmentation

目的研究sticky bone混合浓缩生长因子(CGF)在水平骨量缺损患者中的骨增量效果。方法选取2021年9月至2023年2月于济南市口腔医院口腔颌面外科就诊的拟行水平骨增量的单颗牙缺失患者共40例,使用随机数表法将其分为使用Bio-Oss骨粉行引导骨再生术(GBR)的对照组和使用sticky bone混合CGF行GBR的研究组,比较两组术后6个月的种植体骨结合成功率、种植位点的牙槽骨宽度、骨增量宽度、植骨手术时间及术后并发症等。结果术后6个月,两组受试者的种植体骨结合成功率均为100%;研究组和对照组术后6个月的牙槽骨宽度分别为(8.3±0.8)、(7.1±1.0)mm,均大于术前[(3.6±0.6)、(3.8±0.8)mm],差异均有统计学意义(t研究组=22.13,t对照组=11.99,P均<0.001);术后6个月时,研究组的牙槽骨宽度(t2)、骨增量宽度(t2-t0)分别为(8.3±0.8)、(4.7±0.7)mm,均高于对照组[(7.1±1.0)、(3.3±0.8)mm],差异有统计学意义(tt2=-4.406,tt2-t0=5.978,P<0.001);研究组植骨手术时间[(6.5±1.1)min]显著低于对照组[(8.1±1.3)min],差异有统计学意义(t=4.196,P<0.001);40例受试者均未出现严重术后并发症。结论与使用Bio-Oss骨粉的GBR技术相比,使用sticky bone混合CGF的GBR技术具有更好的水平骨增量效果,其远期效果仍需进一步研究。

Objective To study the effectiveness of sticky bone mixed with concentrated growth factor(CGF)on bone augmentation in patients with horizontal ridge defect.Methods A total of 40 patients with dentition defect(one tooth loss)who were treated in the Department of Oral and Maxillofacial Surgery,Jinan Stomatological Hospital from September 2021 to February 2023 were included in the study.Participants were randomly divided into the control group receiving guided bone regeneration(GBR)with Bio-Oss bone substitute,and the experimental group receiving GBR with sticky bone mixed with CGF.The success rate of osseointegration,alveolar bone width,gained bone width at 6 months after surgery,operation time and postoperative complications were compared between the two groups.Results The success rate of osseointegration in both groups was 100%.The alveolar bone width of the experimental group and the control group at 6 months after surgery was(8.3±0.8)mm and(7.1±1.0)mm,respectively,both of which was larger than that before surgery[(3.6±0.6)mm and(3.8±0.8)mm],and the difference was statistically significant(te=22.13,tc=11.99,P<0.001).The alveolar bone width(t2)and gained bone width(t2-t0)in the experimental group were(8.3±0.8)mm and(4.7±0.7)mm,respectively,which were higher than those in the control group[(7.1±1.0)mm and(3.3±0.8)mm],and the difference was statistically significant(tt2=-4.406,tt2-t0=5.978,P<0.001).The operation time of bone augmentation in the experimental group[(6.5±1.1)min]was significantly lower than that in the control group[(8.1±1.3)min](t=4.196,P<0.001).No serious postoperative complications occurred.Conclusions Compared with the GBR technique using Bio-Oss bone substitute,the GBR technique using sticky bone mixed with CGF had better outcome in horizontal bone augmentation.However,further studies on its long-term effect are needed.