近红外二区荧光成像技术的临床研究进展

Clinical research progress on the fluorescence imaging in the second near-infrared window

近红外荧光成像是外科手术中实现术中导航的关键技术之一。近些年随着近红外二区(NIR-II,900~1700nm)光学生物成像理论的日趋成熟,NIR-II荧光成像技术成为临床手术导航领域的一大研究热点。本文基于NIRII光学生物成像理论,简要介绍了NIR-II荧光探针及成像系统的发展现状,就NIR-II荧光成像技术在活体小动物手术与人体临床手术中的研究展开综述,讨论了该技术在未来临床手术中的发展潜力以及临床转化中需要面临的难点。

The near-infrared fluorescence imaging is a vital technology that enables the image-guided surgery.In recent years,the maturation of the optical bioimaging theory in the second near-infrared window(NIR-II,900-1700 nm)has led to the emergence of NIR-II fluorescence imaging as a significant research area in the imaging-guided surgery.This paper provides a succinct overview on the current development state of NIR-II fluorescence probes and imaging systems based on the NIR-II optical bioimaging theory.Furthermore,it reviews the studies conducted on the NIR-II fluorescence imaging in the small animal and clinical surgery,and discusses the potential and challenges of this technology in the clinical surgery,including the difficulties that need to be addressed in the future clinical translation.