布地奈德联合果糖二磷酸钠和维生素C治疗儿童支原体肺炎合并心肌损伤的疗效

Effect of budesonide combined with fructose sodium diphosphate and vitamin C in the treatment of children with mycoplasma pneumonia and myocardial damage

目的探究布地奈德雾化吸入联合果糖二磷酸钠、维生素C治疗儿童支原体肺炎(mycoplasma pneumonia,MP)合并心肌损伤的临床效果。方法选取87例MP合并心肌损伤患儿作为研究对象,用随机数字表法分为A组(44例)与B组(43例)。2组均行常规治疗,在此基础上B组给予布地奈德雾化吸入联合维生素C治疗,A组给予布地奈德雾化吸入联合果糖二磷酸钠和维生素C治疗。观察2组的疗效、不良反应及啰音消失时间、退热时间和咳嗽消失时间,比较2组治疗前后的心肌酶谱[α-羟丁酸脱氢酶(α-hydroxybutyrate dehydrogenase,α-HBDH)、肌酸肌酶同工酶(creatine kinase-MB,CK-MB)、乳酸脱氢酶(lactate dehydrogenase,LDH)]和炎症指标[降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)、白细胞介素6(interleukin-6,IL-6)]。结果A组的治疗总有效率(93.18%)高于B组(76.74%)(P<0.05);A组的啰音消失时间、退热时间和咳嗽消失时间均短于B组(P<0.05);2组治疗后的HBDH、CK-MB、LDH、PCT、CRP及IL-6均低于治疗前,且A组低于B组(P<0.05);2组不良反应的总发生率比较差异无统计学意义(P>0.05)。结论布地奈德雾化吸入联合果糖二磷酸钠、维生素C治疗儿童MP合并心肌损伤的临床效果较好,可明显改善患儿的肺部症状和体征,抑制炎症,促进心肌功能恢复。

Objective To explore the clinical effects of budesonide aerosol inhalation combined with fructose sodium diphosphate and vitamin C in the treatment of children with mycoplasma pneumonia(MP)and myocardial damage.Methods 87 children with MP and myocardial damage were enrolled and divided into group A(44 cases)and group B(43 cases)by random number table method.The both groups were given conventional treatments.On this basis,the children in group B were treated with budesonide aerosol inhalation combined with vitamin C,while the children in group A were treated with budesonide aerosol inhalation combined with fructose sodium diphosphate and vitamin C.The curative effects,adverse reactions and the disappearance time of rales,fever,and cough in the 2 groups were observed.Myocardial enzymes[α-hydroxybutyrate dehydrogenase(HBDH),creatine kinase-MB(CK-MB)and lactate dehydrogenase(LDH)],inflammation indicators[procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)]were compared between the 2 groups before and after treatment.Results The total treatment response rate in group A(93.18%)was higher than in group B(76.74%)(P<0.05).The disappearance time of rales,fever and cough in group A was shorter than that in group B(P<0.05).After treatment,the levels of HBDH,CK-MB,LDH,PCT,CRP and IL-6 were reduced,which were lower in group A than in group B(P<0.05).There was no difference in the total incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Budesonide aerosol inhalation combined with fructose sodium diphosphate and vitamin C is effective in the treatment of children with MP and myocardial damage,which can significantly improve pulmonary symptoms and signs,inhibit inflammation and promote myocardial function recovery.