卡维地洛联合尼可地尔治疗冠心病心绞痛的效果

Effect of carvedilol combined with nicodil on angina pectoris in patients with coronary heart disease

目的探究卡维地洛联合尼可地尔对冠心病(coronary heart disease,CHD)心绞痛患者外周血微粒(microparticles,MP)、对氧磷酯酶1(paraoxophosphorase-1,PON1)及髓过氧化物酶/对氧磷酯酶-1(myeloperoxidase/paraoxophosphorase-1,MPO/PON1)的影响。方法选取CHD心绞痛患者69例,分为观察组(n=30)和对照组(n=39)。对照组在常规治疗的基础上给予卡维地洛治疗,观察组在对照组治疗的基础上给予尼可地尔。比较2组临床疗效、左室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)、左室射血分数(left ventricular ejection fraction,LVEF)、左室收缩末期内径(left ventricular end-systolic diameter,LVESD)等心功能指标;比较血小板微粒(platelet microparticles,PMP)、内皮细胞源微粒(endothelial cell derived microparticles,EMP)和红细胞微粒(erythrocyte microparticles,RMP)等指标;比较PON1和MPO/PON1水平;比较心绞痛发作的次数和持续时间。结果观察组的临床治疗总有效率为96.67%,显著高于对照组的79.49%(P<0.05)。治疗后,观察组患者LVEF水平显著高于对照组,LVEDD和LVESD水平显著低于对照组(P<0.05);观察组PMP、EMP和RMP显著低于对照组(P<0.05);观察组PON1水平显著高于对照组;MPO和MPO/PON1水平显著低于对照组(P<0.05);观察组心绞痛发作的次数和时间显著少(短)于对照组(P<0.05)。结论卡维地洛联合尼可地尔治疗有利于增强CHD心绞痛患者的临床疗效,改善患者的心功能,降低患者外周血MP水平,维持PON1、MPO/PON1水平,同时还可以降低(缩短)患者的心绞痛发生频率和时间。

Objective To investigate the effects of carvedilol combined with nicodil on peripheral blood microparticles(MP),paraoxophosphorase-1(PON1)and myeloperoxidase/paraoxophosphorase-1(MPO/PON1)in patients with angina pectoris of coronary heart disease(CHD).Methods 69 patients with CHD angina pectoris were divided into observation group(n=30)and control group(n=39).The control group was given carvedilol on the basis of conventional treatment,and the observation group was given nicodil on the basis of control group.The clinical efficacy,left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD)and other cardiac function indexes were compared between the 2 groups.The platelet microparticles(PMP),endothelial cell derived microparticles(EMP)and erythrocyte microparticles(RMP)were compared.The PON1 and MPO/PON1 levels,and the number and duration of angina attacks were also compared.Results The total effective rate of the observation group was 96.67%,which was significantly higher than that of the control group(79.49%,P<0.05).After treatment,LVEF levels in observation group were significantly higher than those in control group,the LVEDD and LVESD levels were significantly lower than those in control group(P<0.05);the PMP,EMP and RMP in observation group were significantly lower than those in control group(P<0.05).The PON1 level in the observation group was significantly higher than that in the control group.The levels of MPO and MPO/PON1 were significantly lower than those of control group(P<0.05).The frequency and time of angina pectoris attack in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Carvedilol combined with nicodil can enhance the clinical efficacy of CHD patients with angina pectoris,improve the cardiac function of patients,reduce the MP level in peripheral blood of patients,maintain PON1,MPO/PON1 levels,and reduce(shorten)the frequency and time of angina pectoris in patients.