白癜风的外用药治疗研究进展

Research progress in external drug treatment of vitiligo

目的总结近年来治疗白癜风的外用药的研究进展。方法通过查阅近年来国内外公开发表的文献,归纳总结治疗白癜风的外用药物的作用机制、治疗疗效及不良反应。结果局部皮质类固醇药物、局部钙调神经磷酸酶抑制剂、维生素D类衍生物、5-氟尿嘧啶、前列腺素F2α衍生物、碱性成纤维细胞生长因子衍生肽、Janus激酶(Janus kinase,JAK)抑制剂外用治疗白癜风均有效,而假过氧化氢酶/超氧化物歧化酶(pseudo catalase/superoxide dismutase,PSD)、甲氨蝶呤外用治疗白癜风疗效不确切。结论通过对治疗白癜风的外用药物的综述,对将来新的治疗方式和新药物的研发提供依据。

Objective To summarize the research progress in external drug treatment of vitiligo in recent years.Methods By reviewing the literature published at home and abroad in recent years,the mechanism of action,therapeutic efficacy and adverse reactions of external agents for the treatment of vitiligo were summarized.Results Topical corticosteroids,topical calcineurin inhibitors,vitamin D derivatives,5-fluorouracil,prostaglandin F2αderivatives,basic fibroblast growth factor derived peptide,and Janus kinase(JAK)inhibitors were effective in the treatment of vitiligo,while the efficacy of pseudo-catalase/superoxide dismutase(PSD)and methotrexate in the treatment of vitiligo was not sure.Conclusion By reviewing the external agents for the treatment of vitiligo,it provides guidance for the development of new treatment methods and new drugs in the future.