利水中药治疗肾源性水肿研究进展

Progress of Urination-Promoting Chinese Herbs for Nephrogenic Edema

肾源性水肿是由各种原发性或继发性肾脏疾病引发的水肿,严重影响患者日常生活及健康。中医认为肾源性水肿以脾肾虚为本、水液内停为标,临床治疗以利水为重点。大量研究发现五苓散、猪苓汤、真武汤及其加减方为代表的利水复方临床治疗肾源性水肿疗效显著。茯苓、猪苓、泽泻、白术为代表的单味利水中药能够通过增加电解质排出、升高水通道蛋白的表达来减少水钠潴留;降低炎症因子水平、抗凋亡、抗肾纤维化来改善肾脏损伤,保护肾脏功能。笔者系统总结了利水中药治疗肾源性水肿的研究内容,以期为中医药治疗肾源性水肿提供更多参考。

Nephrogenic edema is caused by various primary or secondary kidney diseases,which seriously affects the daily life and health of patients.Chinese medicine believes spleen-kidney deficiency is the root of nephrogenic edema,and that internal retention of water is the branch,and he also thinks that the emphasis of its treatment is to promote urination.A large number of studies,which have been conducted on urination-promoting compound prescriptions represented by Wuling Powder,Zhuling Decoction,Zhenwu Decoction and their modified ones,showed a significant therapeutic on nephrogenic edema.The urination-promoting Chinese herbs that are used alone,such as Poria,Polyporus,Alismatis Rhizoma and Atractylodis Macrocephalae Rhizoma,can reduce the retention of water and sodium by increasing the electrolyte discharge and the expression of aquaporin,and can reduce the levels of inflammatory factors,resist apoptosis and resist renal fibrosis to relieve kidney injury and protect kidney function.The authors systematically summarize the contents of the researches on using Chinese herbs to treat nephrogenic edema,which aims to provide more reference for the treatment of the disease.