脑心通胶囊联合银杏酮酯滴丸治疗非心源性脑梗死临床研究

Clinical Study on Naoxintong Capsules Combined with Gingko Ketone Ester Dropping Pills for Non-cardiogenic Cerebral Infarction

目的:观察脑心通胶囊联合银杏酮酯滴丸治疗非心源性脑梗死的疗效。方法:选取76例非心源性脑梗死患者,按治疗方式不同分为对照组及观察组各38例。对照组给予脑心通胶囊治疗,观察组给予脑心通胶囊联合银杏酮酯滴丸治疗。观察2组临床疗效及不良反应发生率,比较2组治疗前后血液[红细胞比容(HCT)、血浆黏度(PV)、纤维蛋白原(Fg)、D-二聚体(D-D)]指标值、脑血流动力学[平均血流速度(Vm)、血流量(Qm)、动态阻力(DR)、外周阻力(Rv)]指标值、美国国立卫生院神经功能缺损(NIHSS)评分、日常生活能力量表(ADL)评分的变化。结果:治疗4周后,观察组临床疗效总有效率为92.11%,对照组为71.05%,2组比较,差异有统计学意义(P<0.05)。治疗4周后,观察组不良反应发生率为18.42%,对照组为15.79%,2组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗4周后,2组HCT、PV、Fg、D-D指标值均较治疗前下降(P<0.05),观察组上述4项指标值均小于对照组(P<0.05)。治疗4周后,2组Vm、Qm指标值均较治疗前升高(P<0.05),DR、Rv指标值均较治疗前下降(P<0.05);观察组Vm、Qm指标值均高于对照组(P<0.05),DR、Rv指标值均低于对照组(P<0.05)。治疗4周后,2组NIHSS评分、ADL评分均较治疗前升高(P<0.05),观察组上述2项评分均高于对照组(P<0.05)。结论:脑心通胶囊联合银杏酮酯滴丸治疗非心源性脑梗死能提升临床疗效,增加脑血流量,促进神经恢复及提高预后质量,安全性高。

Objective:To observe the curative effect of Naoxintong Capsules combined with Gingko Ketone Ester Dropping Pills on non-cardiogenic cerebral infarction.Methods:A total of 76 cases of patients with non-cardiogenic cerebral infarction were selected and divided into the control group and the observation group according to different treatment methods,with 38 cases in each group.The control group was treated with Naoxintong Capsules,and the observation group was treated with Naoxintong Capsules combined with Gingko Ketone Ester Dropping Pills.Clinical effects and the incidence of adverse reactions were observed in the two groups.The changes in blood indexes[hematocrit(HCT),plasma viscosity(PV),fibrinogen(Fg),and D-dimer(D-D)],cerebral hemodynamics indexes[mean blood flow velocity(Vm),blood flow(Qm),dynamic resistance(DR),and peripheral resistance(Rv)],and the scores of National Institute of Health Stroke Scale(NIHSS)and Activities of Daily Living(ADL)Scale during treatment were compared between the two groups before and after treatment.Results:After 4 weeks of treatment,the total clinical effective rate was 92.11%in the observation group and 71.05%in the control group,the difference being significant(P<0.05).After 4 weeks of treatment,the incidence of adverse reactions was 18.42%in the observation group and 15.79%in the control group,no significant difference being found in the comparison(P>0.05).After 4 weeks of treatment,the levels of HCT,PV,Fg,and DD in the two groups were decreased when compared with those before treatment(P<0.05),and the above four indexes in the observation group were lower than those in the control group(P<0.05).After 4 weeks of treatment,Vm and Qm in the two groups were increased when compared with those before treatment(P<0.05),and DR and Rv were decreased when compared with those before treatment(P<0.05);Vm and Qm in the observation group were higher than those in the control group(P<0.05),and DR and Rv in the observation group were lower than those in the control group(P<0.05).After 4 weeks of treatment,NIHSS scores and ADL scores in the two groups were increased when compared with those before treatment(P<0.05),and the above two scores in the observation group were larger than those in the control group(P<0.05).Conclusion:In the treatment of non-cardiogenic cerebral infarction,Naoxintong Capsules combined with Gingko Ketone Ester Dropping Pills can improve clinical effects and cerebral blood flow,promote neurological recovery,and enhance the quality of prognosis,with high safety.